NHERF4 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of NHERF4 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	2480.72	89 / 89	81%	7.51	731 / 901
intestine	86%	1719.57	834 / 966	81%	5.17	428 / 527
pancreas	93%	51.54	306 / 328	74%	6.59	132 / 178
stomach	88%	222.98	316 / 359	69%	4.07	196 / 286
bladder	76%	43.86	16 / 21	39%	2.23	196 / 504
adipose	90%	90.29	1079 / 1204	0%	0	0 / 0
lung	68%	17.24	392 / 578	10%	0.39	119 / 1155
liver	67%	15.74	151 / 226	5%	0.20	22 / 406
breast	72%	16.06	330 / 459	0%	0	0 / 1118
spleen	70%	9.76	168 / 241	0%	0	0 / 0
peripheral blood	65%	16.38	604 / 929	0%	0	0 / 0
skin	63%	11.21	1132 / 1809	0%	0	0 / 472
esophagus	33%	5.15	479 / 1445	29%	1.09	53 / 183
prostate	51%	6.12	126 / 245	0%	0	0 / 502
ovary	44%	10.73	79 / 180	4%	0.10	17 / 430
thymus	45%	4.82	296 / 653	0%	0.01	2 / 605
uterus	37%	16.55	63 / 170	8%	0.38	36 / 459
blood vessel	33%	5.14	446 / 1335	0%	0	0 / 0
heart	27%	15.67	234 / 861	0%	0	0 / 0
brain	25%	2.86	659 / 2642	0%	0	0 / 705
muscle	17%	1.49	137 / 803	0%	0	0 / 0
adrenal gland	7%	0.53	18 / 258	0%	0.01	1 / 230
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007168	Biological process	receptor guanylyl cyclase signaling pathway
GO_0006811	Biological process	monoatomic ion transport
GO_0006833	Biological process	water transport
GO_0009636	Biological process	response to toxic substance
GO_0010754	Biological process	negative regulation of cGMP-mediated signaling
GO_0072659	Biological process	protein localization to plasma membrane
GO_0005903	Cellular component	brush border
GO_0016324	Cellular component	apical plasma membrane
GO_0043296	Cellular component	apical junction complex
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0045177	Cellular component	apical part of cell
GO_0030251	Molecular function	guanylate cyclase inhibitor activity
GO_0043495	Molecular function	protein-membrane adaptor activity
GO_0005102	Molecular function	signaling receptor binding
GO_0005515	Molecular function	protein binding
GO_0008200	Molecular function	ion channel inhibitor activity
GO_1990381	Molecular function	ubiquitin-specific protease binding

Gene name	NHERF4
Protein name	NHERF family PDZ scaffold protein 4 Na(+)/H(+) exchange regulatory cofactor NHE-RF4 (NHERF-4) (Intestinal and kidney-enriched PDZ protein) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (Na/Pi cotransporter C-terminal-associated protein 2) (NaPi-Cap2) (PDZ domain-containing protein 2) (PDZ domain-containing protein 3) (Sodium-hydrogen exchanger regulatory factor 4) PDZ domain-containing protein 2 variant 1
Synonyms	IKEPP PDZK2 PDZD3 DLNB27
Description	FUNCTION: Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation . Stimulates SLC9A3 activity in the presence of elevated calcium ions . .
Accessions	E9PRB0 Q86UT5 ENST00000525131.5 ENST00000531114.5 [Q86UT5-1] ENST00000355547.10 [Q86UT5-2] ENST00000533688.5 B0YJ61 E9PPZ1 ENST00000322712.4 [Q86UT5-3]

NHERF4 report