NES report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NES at tissue level.

III. Associated gene sets

GO_0048858Biological processcell projection morphogenesis
GO_0030844Biological processpositive regulation of intermediate filament depolymerization
GO_0043086Biological processnegative regulation of catalytic activity
GO_0051402Biological processneuron apoptotic process
GO_2000179Biological processpositive regulation of neural precursor cell proliferation
GO_0031076Biological processembryonic camera-type eye development
GO_0007417Biological processcentral nervous system development
GO_0007420Biological processbrain development
GO_0000086Biological processG2/M transition of mitotic cell cycle
GO_0032091Biological processnegative regulation of protein binding
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0072089Biological processstem cell proliferation
GO_0005882Cellular componentintermediate filament
GO_0045111Cellular componentintermediate filament cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0031730Molecular functionCCR5 chemokine receptor binding
GO_0019215Molecular functionintermediate filament binding
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameNES
Protein nameNestin
NES protein
SynonymsNbla00170
DescriptionFUNCTION: Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). .

AccessionsQ2YDX4
Q05BW3
ENST00000368223.4
A5PKT9
P48681