Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 25 studies | 27% ± 10% | |
pericyte | 18 studies | 28% ± 12% | |
capillary endothelial cell | 13 studies | 26% ± 4% | |
endothelial cell of artery | 8 studies | 26% ± 12% | |
smooth muscle cell | 6 studies | 27% ± 6% | |
endothelial cell of vascular tree | 5 studies | 27% ± 9% | |
podocyte | 4 studies | 51% ± 21% | |
fibroblast | 4 studies | 20% ± 3% | |
myofibroblast cell | 3 studies | 32% ± 11% | |
neural crest cell | 3 studies | 30% ± 7% | |
connective tissue cell | 3 studies | 27% ± 12% |
Insufficient scRNA-seq data for expression of NES at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 92% | 3021.74 | 2434 / 2642 | 99% | 448.40 | 699 / 705 |
breast | 100% | 7996.08 | 459 / 459 | 78% | 53.48 | 876 / 1118 |
prostate | 100% | 6072.84 | 244 / 245 | 71% | 34.80 | 356 / 502 |
uterus | 99% | 10127.39 | 168 / 170 | 65% | 88.00 | 300 / 459 |
skin | 64% | 2139.72 | 1165 / 1809 | 95% | 405.90 | 449 / 472 |
thymus | 99% | 5904.25 | 644 / 653 | 60% | 30.66 | 366 / 605 |
kidney | 100% | 8072.94 | 89 / 89 | 57% | 44.84 | 518 / 901 |
lung | 100% | 11887.63 | 576 / 578 | 44% | 21.35 | 508 / 1155 |
adrenal gland | 73% | 1911.14 | 188 / 258 | 64% | 39.22 | 147 / 230 |
bladder | 100% | 6778.43 | 21 / 21 | 34% | 19.51 | 172 / 504 |
intestine | 88% | 3850.06 | 854 / 966 | 41% | 20.85 | 216 / 527 |
stomach | 72% | 2177.68 | 258 / 359 | 44% | 22.81 | 125 / 286 |
esophagus | 80% | 3631.03 | 1152 / 1445 | 29% | 11.63 | 53 / 183 |
ovary | 75% | 2401.67 | 135 / 180 | 26% | 10.59 | 112 / 430 |
adipose | 100% | 9246.01 | 1204 / 1204 | 0% | 0 | 0 / 0 |
heart | 100% | 20495.11 | 861 / 861 | 0% | 0 | 0 / 0 |
spleen | 100% | 13519.47 | 241 / 241 | 0% | 0 | 0 / 0 |
muscle | 99% | 7908.64 | 794 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 95% | 5003.41 | 1269 / 1335 | 0% | 0 | 0 / 0 |
pancreas | 14% | 262.65 | 45 / 328 | 74% | 37.24 | 132 / 178 |
eye | 0% | 0 | 0 / 0 | 80% | 71.85 | 64 / 80 |
liver | 9% | 217.00 | 21 / 226 | 33% | 18.21 | 135 / 406 |
tonsil | 0% | 0 | 0 / 0 | 40% | 24.05 | 18 / 45 |
lymph node | 0% | 0 | 0 / 0 | 14% | 3.64 | 4 / 29 |
peripheral blood | 0% | 1.91 | 1 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0048858 | Biological process | cell projection morphogenesis |
GO_0030844 | Biological process | positive regulation of intermediate filament depolymerization |
GO_0043086 | Biological process | negative regulation of catalytic activity |
GO_0051402 | Biological process | neuron apoptotic process |
GO_2000179 | Biological process | positive regulation of neural precursor cell proliferation |
GO_0031076 | Biological process | embryonic camera-type eye development |
GO_0007417 | Biological process | central nervous system development |
GO_0007420 | Biological process | brain development |
GO_0000086 | Biological process | G2/M transition of mitotic cell cycle |
GO_0032091 | Biological process | negative regulation of protein binding |
GO_0043524 | Biological process | negative regulation of neuron apoptotic process |
GO_0072089 | Biological process | stem cell proliferation |
GO_0005882 | Cellular component | intermediate filament |
GO_0045111 | Cellular component | intermediate filament cytoskeleton |
GO_0005737 | Cellular component | cytoplasm |
GO_0031730 | Molecular function | CCR5 chemokine receptor binding |
GO_0019215 | Molecular function | intermediate filament binding |
GO_0005515 | Molecular function | protein binding |
GO_0003674 | Molecular function | molecular_function |
Gene name | NES |
Protein name | Nestin NES protein |
Synonyms | Nbla00170 |
Description | FUNCTION: Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). . |
Accessions | Q2YDX4 Q05BW3 ENST00000368223.4 A5PKT9 P48681 |