NELL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071679Biological processcommissural neuron axon guidance
GO_0070050Biological processneuron cellular homeostasis
GO_0009566Biological processfertilization
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005737Cellular componentcytoplasm
GO_0005080Molecular functionprotein kinase C binding
GO_0008201Molecular functionheparin binding
GO_0005509Molecular functioncalcium ion binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNELL2
Protein nameNeural EGFL like 2
Alternative protein NELL2
Protein kinase C-binding protein NELL2 (NEL-like protein 2) (Nel-related protein 2)
Protein kinase C-binding protein NELL2 (NEL-like protein 2)
SynonymsNRP2
DescriptionFUNCTION: Plays multiple roles in neural tissues, regulates neuronal proliferation, survival, differentiation, polarization, as well as axon guidance and synaptic functions. Plays an important role in axon development during neuronal differentiation through the MAPK intracellular signaling pathway (By similarity). Via binding to its receptor ROBO3, plays a role in axon guidance, functioning as a repulsive axon guidance cue that contributes to commissural axon guidance to the midline . Required for neuron survival through the modulation of MAPK signaling pathways too. Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity). .; FUNCTION: Epididymal-secreted protein that signals through a ROS1-pathway to regulate the epididymal initial segment (IS) maturation, sperm maturation and male fertility. .

AccessionsENST00000429094.7 [Q99435-1]
ENST00000333837.8 [Q99435-2]
F8W1A2
ENST00000437801.6 [Q99435-3]
F8VZ72
F8VRQ0
F8VVB6
ENST00000551601.5
L0R6L1
ENST00000551949.1
ENST00000549027.5 [Q99435-4]
ENST00000550462.5
Q99435
ENST00000548826.5
ENST00000395487.6 [Q99435-4]
ENST00000550139.1
F8W1I8
ENST00000553120.1
H0YHY5
H0YI34
ENST00000552993.5
ENST00000452445.6 [Q99435-1]
H0YIT4
ENST00000548531.1
ENST00000550313.5
F8VXR5