NEK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0051301Biological processcell division
GO_0006468Biological processprotein phosphorylation
GO_0034451Cellular componentcentriolar satellite
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000242Cellular componentpericentriolar material
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0071889Molecular function14-3-3 protein binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0016301Molecular functionkinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNEK1
Protein namenon-specific serine/threonine protein kinase (EC 2.7.11.1)
NIMA related kinase 1
Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55)
SynonymsKIAA1901
DescriptionFUNCTION: Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity . Involved in DNA damage checkpoint control and for proper DNA damage repair . In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death . May be implicated in the control of meiosis (By similarity). Involved in cilium assembly . .

AccessionsENST00000507142.6 [Q96PY6-3]
A0A8I5QJM8
ENST00000687219.1
ENST00000512193.5 [Q96PY6-4]
ENST00000510533.5 [Q96PY6-2]
ENST00000687528.1
ENST00000692868.1
ENST00000439128.6 [Q96PY6-1]
D6RBG5
ENST00000686697.1
ENST00000505119.2
A0A8I5KT19
ENST00000685111.1
ENST00000688934.1
ENST00000693085.1
A0A8I5QL42
ENST00000510108.1
A0A8I5KUL6
ENST00000692450.1
ENST00000693604.1
ENST00000687643.1
ENST00000511633.5 [Q96PY6-6]
A0A8I5KWD5
A0A8I5KQ77
A0A8I5KSI3
H0Y8M6
A0A8I5KRM5
Q96PY6