Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| B cell | 11 studies | 26% ± 10% | |
| ciliated cell | 10 studies | 24% ± 8% | |
| naive B cell | 6 studies | 22% ± 8% | |
| precursor B cell | 5 studies | 47% ± 6% | |
| epithelial cell | 4 studies | 24% ± 4% | |
| immature B cell | 4 studies | 43% ± 15% | |
| germinal center B cell | 4 studies | 39% ± 18% | |
| astrocyte | 4 studies | 19% ± 2% | |
| endothelial cell | 3 studies | 18% ± 2% | |
| pro-B cell | 3 studies | 35% ± 3% | |
| GABAergic neuron | 3 studies | 35% ± 9% | |
| glutamatergic neuron | 3 studies | 47% ± 16% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 34% ± 16% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 2859.13 | 245 / 245 | 99% | 10.99 | 498 / 502 |
| thymus | 100% | 2487.25 | 653 / 653 | 96% | 8.77 | 580 / 605 |
| brain | 98% | 1818.95 | 2602 / 2642 | 95% | 7.17 | 670 / 705 |
| pancreas | 100% | 1199.97 | 328 / 328 | 92% | 7.92 | 163 / 178 |
| bladder | 100% | 1516.48 | 21 / 21 | 88% | 6.77 | 443 / 504 |
| adrenal gland | 100% | 2707.57 | 258 / 258 | 87% | 6.45 | 201 / 230 |
| breast | 100% | 2387.80 | 459 / 459 | 87% | 7.46 | 975 / 1118 |
| intestine | 100% | 1787.39 | 966 / 966 | 85% | 4.92 | 449 / 527 |
| liver | 100% | 1475.88 | 225 / 226 | 83% | 4.67 | 337 / 406 |
| lung | 100% | 1812.98 | 578 / 578 | 77% | 5.19 | 889 / 1155 |
| esophagus | 100% | 1397.30 | 1444 / 1445 | 77% | 3.57 | 140 / 183 |
| uterus | 100% | 2260.81 | 170 / 170 | 76% | 5.27 | 349 / 459 |
| stomach | 100% | 1486.58 | 359 / 359 | 72% | 3.93 | 206 / 286 |
| kidney | 100% | 1828.09 | 89 / 89 | 72% | 5.01 | 645 / 901 |
| ovary | 100% | 2309.91 | 180 / 180 | 63% | 3.02 | 271 / 430 |
| skin | 90% | 1051.95 | 1626 / 1809 | 51% | 2.85 | 241 / 472 |
| adipose | 100% | 1496.58 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2523.20 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 7.72 | 1 / 1 |
| blood vessel | 98% | 941.70 | 1313 / 1335 | 0% | 0 | 0 / 0 |
| heart | 95% | 704.34 | 819 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 79% | 11.22 | 23 / 29 |
| peripheral blood | 78% | 656.82 | 720 / 929 | 0% | 0 | 0 / 0 |
| muscle | 76% | 355.19 | 611 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 49% | 1.86 | 39 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 40% | 1.81 | 18 / 45 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006287 | Biological process | base-excision repair, gap-filling |
| GO_0006284 | Biological process | base-excision repair |
| GO_0032074 | Biological process | negative regulation of nuclease activity |
| GO_0006979 | Biological process | response to oxidative stress |
| GO_0045008 | Biological process | depyrimidination |
| GO_0005813 | Cellular component | centrosome |
| GO_0005694 | Cellular component | chromosome |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0003906 | Molecular function | DNA-(apurinic or apyrimidinic site) endonuclease activity |
| GO_0140078 | Molecular function | class I DNA-(apurinic or apyrimidinic site) endonuclease activity |
| GO_0019104 | Molecular function | DNA N-glycosylase activity |
| GO_0016798 | Molecular function | hydrolase activity, acting on glycosyl bonds |
| GO_0005515 | Molecular function | protein binding |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0003684 | Molecular function | damaged DNA binding |
| Gene name | NEIL1 |
| Protein name | Nei like DNA glycosylase 1 Endonuclease 8-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (Endonuclease VIII-like 1) (FPG1) (Nei homolog 1) (NEH1) (Nei-like protein 1) |
| Synonyms | |
| Description | FUNCTION: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. . |
| Accessions | ENST00000564784.5 ENST00000568059.1 H3BN83 ENST00000566313.5 H3BQU8 ENST00000569035.5 ENST00000564257.1 H3BT75 Q96FI4 H3BSZ5 ENST00000569506.1 H3BU98 H3BTX5 ENST00000566752.5 ENST00000568519.5 ENST00000355059.9 ENST00000567005.1 ENST00000567657.5 H3BRZ2 ENST00000564500.5 H3BST2 H3BT94 H3BM98 ENST00000565051.5 H3BQE8 ENST00000568881.1 |
