NECAB3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NECAB3 at tissue level.

III. Associated gene sets

GO_0019538Biological processprotein metabolic process
GO_0042984Biological processregulation of amyloid precursor protein biosynthetic process
GO_0009306Biological processprotein secretion
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0000137Cellular componentGolgi cis cisterna
GO_0005783Cellular componentendoplasmic reticulum
GO_0005794Cellular componentGolgi apparatus
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNECAB3
Protein nameN-terminal EF-hand calcium-binding protein 3 (Amyloid-beta A4 protein-binding family A member 2-binding protein) (Nek2-interacting protein 1) (Neuronal calcium-binding protein 3) (X11L-binding protein 51)
N-terminal EF-hand calcium binding protein 3
SynonymsSYTIP2
NIP1
XB51
APBA2BP
DescriptionFUNCTION: Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3. .

AccessionsU3KQC6
U3KQJ7
ENST00000607805.5
ENST00000246190.11 [Q96P71-1]
ENST00000606690.5
ENST00000493590.1
ENST00000473892.1
X6RCW6
ENST00000488489.5
U3KQF5
ENST00000375238.8 [Q96P71-2]
U3KQR6
U3KPZ3
U3KQ06
Q96P71
ENST00000485399.5
ENST00000439478.5
U3KQM7
ENST00000480994.5