NAT10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000154Biological processrRNA modification
GO_0051391Biological processtRNA acetylation
GO_0006417Biological processregulation of translation
GO_0042274Biological processribosomal small subunit biogenesis
GO_0032211Biological processnegative regulation of telomere maintenance via telomerase
GO_0010824Biological processregulation of centrosome duplication
GO_0045727Biological processpositive regulation of translation
GO_0006473Biological processprotein acetylation
GO_1904812Biological processrRNA acetylation involved in maturation of SSU-rRNA
GO_0005730Cellular componentnucleolus
GO_0030496Cellular componentmidbody
GO_0016020Cellular componentmembrane
GO_0032040Cellular componentsmall-subunit processome
GO_0005654Cellular componentnucleoplasm
GO_0005697Cellular componenttelomerase holoenzyme complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0005634Cellular componentnucleus
GO_0070182Molecular functionDNA polymerase binding
GO_1990883Molecular functionrRNA cytidine N-acetyltransferase activity
GO_0051392Molecular functiontRNA N-acetyltransferase activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0000049Molecular functiontRNA binding
GO_0008080Molecular functionN-acetyltransferase activity
GO_0106162Molecular functionmRNA N-acetyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNAT10
Protein nameRNA cytidine acetyltransferase (EC 2.3.1.-) (18S rRNA cytosine acetyltransferase) (N-acetyltransferase 10) (N-acetyltransferase-like protein) (hALP)
N-acetyltransferase 10
NAT10 protein
SynonymsKIAA1709
ALP
DescriptionFUNCTION: RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs . Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation . mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency . Mediates the formation of ac4C at position 1842 in 18S rRNA . May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis . Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation . In addition to RNA acetyltransferase activity, also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro . The relevance of the protein lysine acetyltransferase activity is however unsure in vivo . Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization . Involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation . Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome . .

AccessionsE9PJN6
ENST00000529523.5
ENST00000257829.8 [Q9H0A0-1]
ENST00000531159.6 [Q9H0A0-2]
E9PMU0
Q05CW7
ENST00000527971.5
Q9H0A0