NAGK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032495Biological processresponse to muramyl dipeptide
GO_0046835Biological processcarbohydrate phosphorylation
GO_0006044Biological processN-acetylglucosamine metabolic process
GO_0070434Biological processpositive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO_0042742Biological processdefense response to bacterium
GO_0045087Biological processinnate immune response
GO_0006051Biological processN-acetylmannosamine metabolic process
GO_0019262Biological processN-acetylneuraminate catabolic process
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0045127Molecular functionN-acetylglucosamine kinase activity
GO_0160047Molecular functionmuramyl dipeptide kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNAGK
Protein nameN-acetyl-D-glucosamine kinase (EC 2.7.1.59) (GlcNAc kinase)
N-acetylglucosamine kinase
N-acetyl-D-glucosamine kinase (N-acetylglucosamine kinase) (EC 2.7.1.59) (GlcNAc kinase) (Muramyl dipeptide kinase) (EC 2.7.1.-) (N-acetyl-D-mannosamine kinase) (EC 2.7.1.60)
Synonyms
DescriptionFUNCTION: Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate . Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded . Also has N-acetylmannosamine (ManNAc) kinase activity (By similarity). Also involved in innate immunity by promoting detection of bacterial peptidoglycan by NOD2: acts by catalyzing phosphorylation of muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, to generate 6-O-phospho-muramyl dipeptide, which acts as a direct ligand for NOD2 . .

AccessionsENST00000455197.5
H0YE82
ENST00000443872.6
E9PPU6
H0YC94
ENST00000443938.6
ENST00000533981.5
ENST00000450272.5
ENST00000613852.4 [Q9UJ70-2]
ENST00000244204.11 [Q9UJ70-1]
H0YF44
ENST00000531934.5
ENST00000524736.5
H7C286
ENST00000418807.7
C9JEV6
ENST00000524537.1
Q9UJ70
C9JMR7
H0YEB7
ENST00000455662.6 [Q9UJ70-2]
ENST00000529236.1
H7C3G9
H7C1L7