Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| macrophage | 30 studies | 32% ± 12% | |
| non-classical monocyte | 23 studies | 35% ± 13% | |
| classical monocyte | 19 studies | 32% ± 12% | |
| monocyte | 18 studies | 26% ± 9% | |
| conventional dendritic cell | 18 studies | 30% ± 14% | |
| plasmacytoid dendritic cell | 11 studies | 30% ± 10% | |
| myeloid cell | 11 studies | 31% ± 11% | |
| microglial cell | 8 studies | 25% ± 8% | |
| dendritic cell | 8 studies | 32% ± 17% | |
| B cell | 6 studies | 20% ± 4% | |
| endothelial cell | 5 studies | 25% ± 9% | |
| mononuclear phagocyte | 4 studies | 36% ± 17% | |
| leukocyte | 4 studies | 22% ± 7% | |
| fibroblast | 4 studies | 23% ± 9% | |
| plasma cell | 4 studies | 27% ± 8% | |
| epithelial cell | 4 studies | 33% ± 8% | |
| alveolar macrophage | 3 studies | 19% ± 2% | |
| hematopoietic precursor cell | 3 studies | 21% ± 4% | |
| placental villous trophoblast | 3 studies | 25% ± 7% | |
| tissue-resident macrophage | 3 studies | 23% ± 8% | |
| ciliated cell | 3 studies | 24% ± 1% | |
| intermediate monocyte | 3 studies | 42% ± 8% | |
| glutamatergic neuron | 3 studies | 33% ± 11% | |
| neuron | 3 studies | 29% ± 11% | |
| oligodendrocyte | 3 studies | 16% ± 1% | |
| connective tissue cell | 3 studies | 20% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 3182.85 | 180 / 180 | 100% | 25.50 | 430 / 430 |
| prostate | 100% | 2842.31 | 245 / 245 | 100% | 19.03 | 502 / 502 |
| skin | 100% | 3773.92 | 1809 / 1809 | 100% | 26.84 | 472 / 472 |
| uterus | 100% | 2979.91 | 170 / 170 | 100% | 32.25 | 459 / 459 |
| esophagus | 100% | 4668.71 | 1444 / 1445 | 100% | 20.07 | 183 / 183 |
| thymus | 100% | 2827.29 | 653 / 653 | 100% | 27.33 | 604 / 605 |
| lung | 100% | 3234.29 | 577 / 578 | 100% | 24.52 | 1155 / 1155 |
| breast | 100% | 2841.41 | 459 / 459 | 100% | 29.66 | 1116 / 1118 |
| intestine | 100% | 2840.32 | 966 / 966 | 100% | 14.60 | 526 / 527 |
| bladder | 100% | 3254.62 | 21 / 21 | 100% | 31.79 | 503 / 504 |
| stomach | 100% | 2005.10 | 358 / 359 | 100% | 14.99 | 286 / 286 |
| adrenal gland | 100% | 2457.01 | 258 / 258 | 100% | 18.51 | 229 / 230 |
| kidney | 100% | 2378.97 | 89 / 89 | 100% | 20.40 | 897 / 901 |
| pancreas | 100% | 1986.60 | 328 / 328 | 99% | 23.26 | 177 / 178 |
| brain | 99% | 2261.19 | 2625 / 2642 | 100% | 29.32 | 705 / 705 |
| liver | 96% | 1161.57 | 217 / 226 | 98% | 10.95 | 398 / 406 |
| adipose | 100% | 2918.24 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 54.21 | 29 / 29 |
| spleen | 100% | 6941.56 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 34.70 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 15.43 | 1 / 1 |
| peripheral blood | 100% | 6053.15 | 927 / 929 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2959.35 | 1332 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 17.53 | 79 / 80 |
| heart | 95% | 1453.12 | 822 / 861 | 0% | 0 | 0 / 0 |
| muscle | 92% | 1049.01 | 738 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0032495 | Biological process | response to muramyl dipeptide |
| GO_0046835 | Biological process | carbohydrate phosphorylation |
| GO_0006044 | Biological process | N-acetylglucosamine metabolic process |
| GO_0070434 | Biological process | positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway |
| GO_0042742 | Biological process | defense response to bacterium |
| GO_0045087 | Biological process | innate immune response |
| GO_0006051 | Biological process | N-acetylmannosamine metabolic process |
| GO_0019262 | Biological process | N-acetylneuraminate catabolic process |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005829 | Cellular component | cytosol |
| GO_0045127 | Molecular function | N-acetylglucosamine kinase activity |
| GO_0160047 | Molecular function | muramyl dipeptide kinase activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | NAGK |
| Protein name | N-acetyl-D-glucosamine kinase (EC 2.7.1.59) (GlcNAc kinase) N-acetylglucosamine kinase N-acetyl-D-glucosamine kinase (N-acetylglucosamine kinase) (EC 2.7.1.59) (GlcNAc kinase) (Muramyl dipeptide kinase) (EC 2.7.1.-) (N-acetyl-D-mannosamine kinase) (EC 2.7.1.60) |
| Synonyms | |
| Description | FUNCTION: Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate . Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded . Also has N-acetylmannosamine (ManNAc) kinase activity (By similarity). Also involved in innate immunity by promoting detection of bacterial peptidoglycan by NOD2: acts by catalyzing phosphorylation of muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, to generate 6-O-phospho-muramyl dipeptide, which acts as a direct ligand for NOD2 . . |
| Accessions | ENST00000455197.5 H0YE82 ENST00000443872.6 E9PPU6 H0YC94 ENST00000443938.6 ENST00000533981.5 ENST00000450272.5 ENST00000613852.4 [Q9UJ70-2] ENST00000244204.11 [Q9UJ70-1] H0YF44 ENST00000531934.5 ENST00000524736.5 H7C286 ENST00000418807.7 C9JEV6 ENST00000524537.1 Q9UJ70 C9JMR7 H0YEB7 ENST00000455662.6 [Q9UJ70-2] ENST00000529236.1 H7C3G9 H7C1L7 |