NAAA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006670Biological processsphingosine metabolic process
GO_0070291Biological processN-acylethanolamine metabolic process
GO_0006631Biological processfatty acid metabolic process
GO_0070292Biological processN-acylphosphatidylethanolamine metabolic process
GO_0016042Biological processlipid catabolic process
GO_0043202Cellular componentlysosomal lumen
GO_0005764Cellular componentlysosome
GO_0070062Cellular componentextracellular exosome
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0017040Molecular functionN-acylsphingosine amidohydrolase activity
GO_0047412Molecular functionN-(long-chain-acyl)ethanolamine deacylase activity
GO_0016810Molecular functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0102121Molecular functionceramidase activity
GO_0017064Molecular functionfatty acid amide hydrolase activity

IV. Literature review

[source]
Gene nameNAAA
Protein nameN-acylethanolamine-hydrolyzing acid amidase (EC 3.5.1.60) (Acid ceramidase-like protein) (Acylsphingosine deacylase NAAA) (EC 3.5.1.23) (N-acylsphingosine amidohydrolase-like) (ASAH-like protein) [Cleaved into: N-acylethanolamine-hydrolyzing acid amidase subunit alpha; N-acylethanolamine-hydrolyzing acid amidase subunit beta]
N-acylethanolamine acid amidase (cDNA FLJ54891, highly similar to N-acylethanolamine-hydrolyzing acid amidase)
N-acylethanolamine acid amidase
SynonymsPLT
ASAHL
DescriptionFUNCTION: Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine . Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine . .

AccessionsD6R9S9
ENST00000286733.9 [Q02083-1]
ENST00000505594.1
B4DVL2
R4GNC0
ENST00000513045.6
Q02083
H0Y988
ENST00000602782.5
ENST00000507187.2
ENST00000507956.5 [Q02083-2]