MYO5B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0003091Biological processrenal water homeostasis
GO_0030050Biological processvesicle transport along actin filament
GO_0016192Biological processvesicle-mediated transport
GO_0016197Biological processendosomal transport
GO_0007015Biological processactin filament organization
GO_0015031Biological processprotein transport
GO_0016020Cellular componentmembrane
GO_0055037Cellular componentrecycling endosome
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0045179Cellular componentapical cortex
GO_0015629Cellular componentactin cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0031982Cellular componentvesicle
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0016459Cellular componentmyosin complex
GO_0051015Molecular functionactin filament binding
GO_0031267Molecular functionsmall GTPase binding
GO_0000146Molecular functionmicrofilament motor activity
GO_0005524Molecular functionATP binding
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMYO5B
Protein nameMyosin 5B
Unconventional myosin-Vb
Myosin VB
SynonymsKIAA1119
DescriptionFUNCTION: May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Required for proper localization of bile salt export pump ABCB11 at the apical/canalicular plasma membrane of hepatocytes . .

AccessionsQ7Z7A5
A0A8V8TKV2
ENST00000592688.1 [Q9ULV0-3]
ENST00000285039.12 [Q9ULV0-1]
A0A8V8TM52
ENST00000697217.1
Q9ULV0
A0A0A0MR36
ENST00000697219.1
ENST00000324581.10