I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| Mueller cell | 5 studies | 53% ± 26% | |
| type B pancreatic cell | 3 studies | 29% ± 10% | |
| interneuron | 3 studies | 23% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| Mueller cell | 5 studies | 53% ± 26% | |
| type B pancreatic cell | 3 studies | 29% ± 10% | |
| interneuron | 3 studies | 23% ± 7% |
Insufficient scRNA-seq data for expression of MYO3A at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 99% | 106.73 | 88 / 89 | 73% | 3.57 | 657 / 901 |
| pancreas | 99% | 132.64 | 325 / 328 | 41% | 1.26 | 73 / 178 |
| thymus | 97% | 90.15 | 635 / 653 | 43% | 0.85 | 258 / 605 |
| uterus | 36% | 21.88 | 61 / 170 | 50% | 4.08 | 229 / 459 |
| tonsil | 0% | 0 | 0 / 0 | 82% | 8.39 | 37 / 45 |
| blood vessel | 79% | 234.78 | 1055 / 1335 | 0% | 0 | 0 / 0 |
| esophagus | 51% | 39.05 | 730 / 1445 | 25% | 1.12 | 45 / 183 |
| skin | 61% | 54.47 | 1111 / 1809 | 6% | 0.22 | 29 / 472 |
| lung | 50% | 25.68 | 289 / 578 | 17% | 0.63 | 199 / 1155 |
| adipose | 67% | 50.72 | 809 / 1204 | 0% | 0 | 0 / 0 |
| stomach | 58% | 29.16 | 210 / 359 | 5% | 0.17 | 15 / 286 |
| breast | 54% | 36.02 | 250 / 459 | 8% | 0.32 | 94 / 1118 |
| ovary | 20% | 15.98 | 36 / 180 | 42% | 1.59 | 181 / 430 |
| intestine | 53% | 32.85 | 510 / 966 | 6% | 0.16 | 32 / 527 |
| prostate | 51% | 30.73 | 126 / 245 | 0% | 0 | 0 / 502 |
| brain | 45% | 86.82 | 1187 / 2642 | 2% | 0.25 | 14 / 705 |
| bladder | 24% | 8.90 | 5 / 21 | 11% | 0.53 | 54 / 504 |
| spleen | 29% | 10.04 | 71 / 241 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 21% | 0.93 | 6 / 29 |
| liver | 9% | 3.34 | 21 / 226 | 9% | 0.50 | 37 / 406 |
| adrenal gland | 4% | 1.16 | 10 / 258 | 12% | 0.46 | 28 / 230 |
| muscle | 12% | 5.27 | 98 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 9% | 0.34 | 7 / 80 |
| heart | 3% | 0.84 | 23 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 2% | 0.90 | 14 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007601 | Biological process | visual perception |
| GO_0007605 | Biological process | sensory perception of sound |
| GO_0018105 | Biological process | peptidyl-serine phosphorylation |
| GO_0030832 | Biological process | regulation of actin filament length |
| GO_0090103 | Biological process | cochlea morphogenesis |
| GO_0051491 | Biological process | positive regulation of filopodium assembly |
| GO_0046777 | Biological process | protein autophosphorylation |
| GO_0031941 | Cellular component | filamentous actin |
| GO_0032433 | Cellular component | filopodium tip |
| GO_0001917 | Cellular component | photoreceptor inner segment |
| GO_0030175 | Cellular component | filopodium |
| GO_0032426 | Cellular component | stereocilium tip |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0016459 | Cellular component | myosin complex |
| GO_0043531 | Molecular function | ADP binding |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0004672 | Molecular function | protein kinase activity |
| GO_0000146 | Molecular function | microfilament motor activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0060002 | Molecular function | plus-end directed microfilament motor activity |
| GO_0005516 | Molecular function | calmodulin binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0003779 | Molecular function | actin binding |
| Gene name | MYO3A |
| Protein name | Myosin-IIIa (EC 2.7.11.1) MYO3A protein Myosin IIIA |
| Synonyms | |
| Description | FUNCTION: Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing . Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (By similarity). . |
| Accessions | ENST00000478093.2 ENST00000543632.5 ENST00000376302.5 [Q8NEV4-2] ENST00000647478.1 A0A2R8Y5M1 Q0VD65 ENST00000642920.2 [Q8NEV4-1] A0A2R8Y4D5 Q86VY5 F5H0U9 Q8NEV4 |
