MYBL1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MYBL1 at tissue level.

III. Associated gene sets

GO_0140543Biological processpositive regulation of piRNA transcription
GO_0007283Biological processspermatogenesis
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0000278Biological processmitotic cell cycle
GO_0030154Biological processcell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0007141Biological processmale meiosis I
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene nameMYBL1
Protein nameMyb-related protein A (A-Myb) (Myb-like protein 1)
V-myb myeloblastosis viral oncogene homolog (Avian)-like 1
MYB proto-oncogene like 1
SynonymsAMYB
DescriptionFUNCTION: Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' . Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity). Transcriptional activator of SOX30 (By similarity). .

AccessionsENST00000524176.2 [P10243-2]
ENST00000517885.5
Q495G0
P10243
ENST00000522677.8 [P10243-1]
E7EWZ1