MTMR9 | OmnibusX

Name	Number of supported studies	Average coverage
brain	5 studies	30% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1153.99	1445 / 1445	100%	9.42	183 / 183
brain	100%	2218.63	2641 / 2642	100%	16.29	705 / 705
thymus	100%	1197.18	652 / 653	99%	6.10	598 / 605
prostate	100%	1254.17	245 / 245	99%	7.12	495 / 502
breast	100%	1148.65	459 / 459	98%	7.10	1092 / 1118
kidney	100%	853.09	89 / 89	97%	6.36	871 / 901
lung	99%	1107.19	575 / 578	96%	5.12	1111 / 1155
pancreas	98%	566.11	323 / 328	97%	5.34	172 / 178
adrenal gland	100%	889.22	258 / 258	95%	9.04	218 / 230
uterus	100%	1393.41	170 / 170	94%	5.28	430 / 459
skin	100%	1111.07	1806 / 1809	91%	6.25	428 / 472
bladder	100%	1305.48	21 / 21	88%	3.95	442 / 504
stomach	100%	856.02	358 / 359	87%	5.10	250 / 286
intestine	100%	1756.45	966 / 966	80%	3.74	419 / 527
ovary	100%	1094.43	180 / 180	76%	2.81	326 / 430
liver	99%	506.82	223 / 226	37%	1.31	151 / 406
adipose	100%	1298.66	1204 / 1204	0%	0	0 / 0
blood vessel	100%	1288.41	1335 / 1335	0%	0	0 / 0
muscle	100%	1131.74	803 / 803	0%	0	0 / 0
spleen	100%	1107.07	241 / 241	0%	0	0 / 0
heart	99%	1136.95	849 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	5.39	44 / 45
lymph node	0%	0	0 / 0	93%	4.52	27 / 29
eye	0%	0	0 / 0	65%	2.55	52 / 80
peripheral blood	61%	548.63	569 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0010507	Biological process	negative regulation of autophagy
GO_0060304	Biological process	regulation of phosphatidylinositol dephosphorylation
GO_0010922	Biological process	positive regulation of phosphatase activity
GO_0046856	Biological process	phosphatidylinositol dephosphorylation
GO_0006897	Biological process	endocytosis
GO_0050821	Biological process	protein stabilization
GO_0032587	Cellular component	ruffle membrane
GO_0032991	Cellular component	protein-containing complex
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005737	Cellular component	cytoplasm
GO_0030234	Molecular function	enzyme regulator activity
GO_0005515	Molecular function	protein binding
GO_0019903	Molecular function	protein phosphatase binding

Gene name	MTMR9
Protein name	Myotubularin-related protein 9 (Inactive phosphatidylinositol 3-phosphatase 9) Myotubularin related protein 9
Synonyms	MTMR8 C8orf9
Description	FUNCTION: Acts as an adapter for myotubularin-related phosphatases . Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate and MTMR6 binding affinity for phosphorylated phosphatidylinositols . Positively regulates lipid phosphatase MTMR7 catalytic activity (By similarity). Increases MTMR8 catalytic activity towards phosphatidylinositol 3-phosphate . The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels . Stabilizes MTMR8 protein levels . Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles . Negatively regulates autophagy, in part via its association with MTMR8 . Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6 . Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine . .
Accessions	ENST00000646141.3 [Q96QG7-2] ENST00000526292.1 [Q96QG7-2] ENST00000221086.8 [Q96QG7-1] ENST00000530200.1 Q96QG7 E9PR67 ENST00000644306.3 [Q96QG7-1]

MTMR9 report