MTMR6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006470Biological processprotein dephosphorylation
GO_0046856Biological processphosphatidylinositol dephosphorylation
GO_0006897Biological processendocytosis
GO_0006661Biological processphosphatidylinositol biosynthetic process
GO_0032587Cellular componentruffle membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005635Cellular componentnuclear envelope
GO_0005793Cellular componentendoplasmic reticulum-Golgi intermediate compartment
GO_0005737Cellular componentcytoplasm
GO_0004438Molecular functionphosphatidylinositol-3-phosphate phosphatase activity
GO_0106018Molecular functionphosphatidylinositol-3,5-bisphosphate phosphatase activity
GO_0004725Molecular functionprotein tyrosine phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0052629Molecular functionphosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
GO_0004722Molecular functionprotein serine/threonine phosphatase activity

IV. Literature review

[source]
Gene nameMTMR6
Protein namephosphatidylinositol-3-phosphatase (EC 3.1.3.64) (Phosphatidylinositol-3-phosphate phosphatase)
Myotubularin-related protein 6 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64)
Synonyms
DescriptionFUNCTION: Phosphatase that acts on lipids with a phosphoinositol headgroup . Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisphosphate (Probable). Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine . Negatively regulates ER-Golgi protein transport (By similarity). Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles . Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate . Negatively regulates proliferation of reactivated CD4(+) T-cells . In complex with MTMR9, negatively regulates DNA damage-induced apoptosis . The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels . .

AccessionsENST00000381801.6 [Q9Y217-1]
ENST00000482345.2
A0A9L9PXJ0
Q9Y217