Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 9 studies | 22% ± 6% | |
GABAergic neuron | 6 studies | 36% ± 18% | |
oligodendrocyte | 6 studies | 23% ± 7% | |
classical monocyte | 5 studies | 19% ± 5% | |
neuron | 4 studies | 26% ± 6% | |
glutamatergic neuron | 4 studies | 46% ± 14% | |
interneuron | 4 studies | 36% ± 20% | |
naive B cell | 3 studies | 18% ± 3% | |
non-classical monocyte | 3 studies | 23% ± 8% | |
epithelial cell | 3 studies | 19% ± 3% | |
amacrine cell | 3 studies | 22% ± 5% | |
monocyte | 3 studies | 17% ± 2% | |
macrophage | 3 studies | 28% ± 4% | |
astrocyte | 3 studies | 25% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 2350.18 | 2642 / 2642 | 100% | 27.09 | 705 / 705 |
esophagus | 100% | 1862.83 | 1445 / 1445 | 100% | 22.51 | 183 / 183 |
lung | 100% | 2256.97 | 578 / 578 | 100% | 21.42 | 1151 / 1155 |
breast | 100% | 2119.79 | 459 / 459 | 100% | 26.40 | 1114 / 1118 |
pancreas | 100% | 1500.12 | 328 / 328 | 99% | 21.32 | 177 / 178 |
prostate | 100% | 1749.05 | 244 / 245 | 100% | 25.53 | 501 / 502 |
stomach | 100% | 1613.36 | 359 / 359 | 99% | 26.64 | 284 / 286 |
thymus | 100% | 2045.34 | 653 / 653 | 99% | 22.49 | 599 / 605 |
intestine | 100% | 2038.47 | 966 / 966 | 99% | 25.95 | 521 / 527 |
bladder | 100% | 2115.90 | 21 / 21 | 99% | 21.01 | 497 / 504 |
kidney | 100% | 1553.65 | 89 / 89 | 98% | 24.81 | 883 / 901 |
uterus | 100% | 2083.75 | 170 / 170 | 97% | 15.99 | 447 / 459 |
ovary | 100% | 1638.32 | 180 / 180 | 97% | 11.72 | 415 / 430 |
adrenal gland | 100% | 4037.64 | 258 / 258 | 96% | 26.37 | 221 / 230 |
skin | 100% | 2169.86 | 1807 / 1809 | 93% | 25.00 | 439 / 472 |
liver | 100% | 1051.89 | 226 / 226 | 90% | 10.10 | 367 / 406 |
adipose | 100% | 2265.81 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2838.56 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 20.88 | 29 / 29 |
spleen | 100% | 2038.40 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 14.52 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 8.75 | 1 / 1 |
muscle | 100% | 1735.59 | 802 / 803 | 0% | 0 | 0 / 0 |
heart | 98% | 1474.96 | 842 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 93% | 1836.62 | 861 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 66% | 7.60 | 53 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006470 | Biological process | protein dephosphorylation |
GO_0046856 | Biological process | phosphatidylinositol dephosphorylation |
GO_0006897 | Biological process | endocytosis |
GO_0006661 | Biological process | phosphatidylinositol biosynthetic process |
GO_0032587 | Cellular component | ruffle membrane |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005829 | Cellular component | cytosol |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0005635 | Cellular component | nuclear envelope |
GO_0005793 | Cellular component | endoplasmic reticulum-Golgi intermediate compartment |
GO_0005737 | Cellular component | cytoplasm |
GO_0004438 | Molecular function | phosphatidylinositol-3-phosphate phosphatase activity |
GO_0106018 | Molecular function | phosphatidylinositol-3,5-bisphosphate phosphatase activity |
GO_0004725 | Molecular function | protein tyrosine phosphatase activity |
GO_0005515 | Molecular function | protein binding |
GO_0052629 | Molecular function | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity |
GO_0004722 | Molecular function | protein serine/threonine phosphatase activity |
Gene name | MTMR6 |
Protein name | phosphatidylinositol-3-phosphatase (EC 3.1.3.64) (Phosphatidylinositol-3-phosphate phosphatase) Myotubularin-related protein 6 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64) |
Synonyms | |
Description | FUNCTION: Phosphatase that acts on lipids with a phosphoinositol headgroup . Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisphosphate (Probable). Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine . Negatively regulates ER-Golgi protein transport (By similarity). Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles . Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate . Negatively regulates proliferation of reactivated CD4(+) T-cells . In complex with MTMR9, negatively regulates DNA damage-induced apoptosis . The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels . . |
Accessions | ENST00000381801.6 [Q9Y217-1] ENST00000482345.2 A0A9L9PXJ0 Q9Y217 |