MTHFD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001780Biological processneutrophil homeostasis
GO_0019346Biological processtranssulfuration
GO_0009152Biological processpurine ribonucleotide biosynthetic process
GO_0007507Biological processheart development
GO_0061053Biological processsomite development
GO_0006730Biological processone-carbon metabolic process
GO_0035999Biological processtetrahydrofolate interconversion
GO_0006555Biological processmethionine metabolic process
GO_0048703Biological processembryonic viscerocranium morphogenesis
GO_0009070Biological processserine family amino acid biosynthetic process
GO_0009086Biological processmethionine biosynthetic process
GO_0001843Biological processneural tube closure
GO_0048702Biological processembryonic neurocranium morphogenesis
GO_0006164Biological processpurine nucleotide biosynthetic process
GO_0009069Biological processserine family amino acid metabolic process
GO_0009257Biological process10-formyltetrahydrofolate biosynthetic process
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0004477Molecular functionmethenyltetrahydrofolate cyclohydrolase activity
GO_0004486Molecular functionmethylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
GO_0004329Molecular functionformate-tetrahydrofolate ligase activity
GO_0004487Molecular functionmethylenetetrahydrofolate dehydrogenase (NAD+) activity
GO_0005524Molecular functionATP binding
GO_0004488Molecular functionmethylenetetrahydrofolate dehydrogenase (NADP+) activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMTHFD1
Protein namemethenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)
Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
C-1-tetrahydrofolate synthase, cytoplasmic (EC 6.3.4.3)
C-1-tetrahydrofolate synthase, cytoplasmic (EC 1.5.1.5) (EC 3.5.4.9) (EC 6.3.4.3)
C-1-tetrahydrofolate synthase, cytoplasmic (EC 1.5.1.5) (EC 3.5.4.9)
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]
SynonymsMTHFC
MTHFD
DescriptionFUNCTION: Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate . These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance . .

AccessionsF5H2F4
ENST00000697175.1
ENST00000697168.1
A0A8V8TMA9
ENST00000697171.1
ENST00000697167.1
A0A8C8UXK2
V9GZ32
A0A8V8TMA4
ENST00000557539.2
ENST00000545908.6
ENST00000554739.5
V9GYY3
A0A8V8TKT4
ENST00000697173.1
ENST00000652509.1
ENST00000697176.1
ENST00000652179.1
ENST00000697169.1
ENST00000557370.3
ENST00000555709.7
ENST00000554768.6
A0A8V8TKS0
A0A8V8TL50
P11586
A0A8V8TL46
ENST00000652337.1
ENST00000651537.1
ENST00000697174.1
V9GZ78
A0A494C1T2
A0A8V8TKR5