MTF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010038Biological processresponse to metal ion
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0071294Biological processcellular response to zinc ion
GO_1990079Biological processcartilage homeostasis
GO_0046686Biological processresponse to cadmium ion
GO_0006351Biological processDNA-templated transcription
GO_0007417Biological processcentral nervous system development
GO_0006979Biological processresponse to oxidative stress
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0035035Molecular functionhistone acetyltransferase binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMTF1
Protein nameMetal regulatory transcription factor 1 (MRE-binding transcription factor) (Transcription factor MTF-1)
Synonyms
DescriptionFUNCTION: Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals . Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A . Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (By similarity). .

AccessionsQ14872
ENST00000373036.5