Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| type II pneumocyte | 11 studies | 39% ± 18% | |
| epithelial cell | 10 studies | 33% ± 14% | |
| astrocyte | 9 studies | 27% ± 7% | |
| ciliated cell | 9 studies | 30% ± 8% | |
| endothelial cell | 7 studies | 25% ± 9% | |
| neuron | 6 studies | 27% ± 10% | |
| retinal ganglion cell | 6 studies | 54% ± 27% | |
| basal cell | 6 studies | 33% ± 9% | |
| oligodendrocyte precursor cell | 6 studies | 30% ± 18% | |
| club cell | 5 studies | 24% ± 3% | |
| hepatocyte | 5 studies | 54% ± 25% | |
| GABAergic neuron | 5 studies | 29% ± 7% | |
| goblet cell | 5 studies | 21% ± 6% | |
| fibroblast | 4 studies | 21% ± 5% | |
| retinal pigment epithelial cell | 4 studies | 33% ± 19% | |
| secretory cell | 4 studies | 29% ± 13% | |
| glutamatergic neuron | 4 studies | 47% ± 8% | |
| oligodendrocyte | 4 studies | 22% ± 10% | |
| ionocyte | 3 studies | 25% ± 4% | |
| connective tissue cell | 3 studies | 24% ± 7% | |
| enterocyte | 3 studies | 23% ± 5% | |
| progenitor cell | 3 studies | 32% ± 11% | |
| amacrine cell | 3 studies | 28% ± 7% | |
| retinal cone cell | 3 studies | 21% ± 1% | |
| respiratory goblet cell | 3 studies | 20% ± 4% | |
| pancreatic ductal cell | 3 studies | 43% ± 17% | |
| interneuron | 3 studies | 24% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 15730.15 | 226 / 226 | 100% | 229.39 | 406 / 406 |
| brain | 98% | 3752.87 | 2597 / 2642 | 100% | 111.46 | 703 / 705 |
| kidney | 100% | 3021.10 | 89 / 89 | 98% | 48.20 | 879 / 901 |
| lung | 98% | 5830.02 | 569 / 578 | 99% | 91.96 | 1143 / 1155 |
| adrenal gland | 100% | 8815.84 | 257 / 258 | 97% | 261.43 | 223 / 230 |
| prostate | 97% | 2553.76 | 238 / 245 | 99% | 75.27 | 498 / 502 |
| ovary | 93% | 2269.16 | 167 / 180 | 97% | 47.76 | 415 / 430 |
| thymus | 89% | 1291.01 | 583 / 653 | 99% | 58.11 | 597 / 605 |
| skin | 100% | 5578.95 | 1808 / 1809 | 86% | 44.25 | 406 / 472 |
| breast | 86% | 1600.19 | 394 / 459 | 99% | 78.40 | 1109 / 1118 |
| stomach | 87% | 2111.58 | 313 / 359 | 97% | 77.88 | 277 / 286 |
| intestine | 79% | 2124.41 | 765 / 966 | 99% | 99.38 | 521 / 527 |
| uterus | 79% | 1606.39 | 134 / 170 | 98% | 78.76 | 452 / 459 |
| esophagus | 77% | 4969.97 | 1114 / 1445 | 98% | 89.53 | 180 / 183 |
| pancreas | 73% | 1097.48 | 238 / 328 | 99% | 95.99 | 176 / 178 |
| bladder | 71% | 1332.90 | 15 / 21 | 99% | 91.99 | 499 / 504 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 93.44 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 47.17 | 1 / 1 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 34.49 | 28 / 29 |
| adipose | 85% | 1486.30 | 1025 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 77% | 1147.86 | 1034 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 74% | 854.41 | 179 / 241 | 0% | 0 | 0 / 0 |
| heart | 43% | 689.87 | 374 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 34% | 1402.80 | 316 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 9% | 2.12 | 7 / 80 |
| muscle | 3% | 22.90 | 21 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0016126 | Biological process | sterol biosynthetic process |
| GO_0008202 | Biological process | steroid metabolic process |
| GO_0006695 | Biological process | cholesterol biosynthetic process |
| GO_0006631 | Biological process | fatty acid metabolic process |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005506 | Molecular function | iron ion binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0000254 | Molecular function | C-4 methylsterol oxidase activity |
| Gene name | MSMO1 |
| Protein name | Methylsterol monooxygenase 1 (EC 1.14.18.9) (C-4 methylsterol oxidase) (Sterol-C4-methyl oxidase) Methylsterol monooxygenase 1 |
| Synonyms | DESP4 SC4MOL ERG25 |
| Description | FUNCTION: Catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, which can be subsequently metabolized to cholesterol . Also involved in drug metabolism, as it can metabolize eldecalcitol (ED-71 or 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol), a second-generation vitamin D analog, into 1alpha,2beta,25-trihydroxy vitamin D3; this reaction occurs via enzymatic hydroxylation and spontaneous O-dehydroxypropylation . . |
| Accessions | Q15800 ENST00000261507.11 [Q15800-1] ENST00000504317.1 ENST00000507013.5 ENST00000393766.6 [Q15800-2] D6RDP9 ENST00000505270.1 D6R952 D6REA2 |