MSMO1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016126Biological processsterol biosynthetic process
GO_0008202Biological processsteroid metabolic process
GO_0006695Biological processcholesterol biosynthetic process
GO_0006631Biological processfatty acid metabolic process
GO_0005783Cellular componentendoplasmic reticulum
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005506Molecular functioniron ion binding
GO_0005515Molecular functionprotein binding
GO_0000254Molecular functionC-4 methylsterol oxidase activity

IV. Literature review

[source]
Gene nameMSMO1
Protein nameMethylsterol monooxygenase 1 (EC 1.14.18.9) (C-4 methylsterol oxidase) (Sterol-C4-methyl oxidase)
Methylsterol monooxygenase 1
SynonymsDESP4
SC4MOL
ERG25
DescriptionFUNCTION: Catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, which can be subsequently metabolized to cholesterol . Also involved in drug metabolism, as it can metabolize eldecalcitol (ED-71 or 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol), a second-generation vitamin D analog, into 1alpha,2beta,25-trihydroxy vitamin D3; this reaction occurs via enzymatic hydroxylation and spontaneous O-dehydroxypropylation . .

AccessionsQ15800
ENST00000261507.11 [Q15800-1]
ENST00000504317.1
ENST00000507013.5
ENST00000393766.6 [Q15800-2]
D6RDP9
ENST00000505270.1
D6R952
D6REA2