MSL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0016567Biological processprotein ubiquitination
GO_0040029Biological processepigenetic regulation of gene expression
GO_0006513Biological processprotein monoubiquitination
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0072487Cellular componentMSL complex
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding
GO_0140585Molecular functionpromoter-enhancer loop anchoring activity
GO_0046872Molecular functionmetal ion binding
GO_0141054Molecular functionhistone H2B ubiquitin ligase activity

IV. Literature review

[source]
Gene nameMSL2
Protein nameE3 ubiquitin-protein ligase MSL2 (EC 2.3.2.-) (E3 ubiquitin-protein transferase MSL2) (Male-specific lethal 2-like 1) (MSL2-like 1) (Male-specific lethal-2 homolog) (MSL-2) (Male-specific lethal-2 homolog 1) (RING finger protein 184)
MSL complex subunit 2
E3 ubiquitin-protein ligase MSL2
SynonymsRNF184
MSL2L1
KIAA1585
DescriptionFUNCTION: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. .

AccessionsENST00000473093.2 [Q9HCI7-2]
ENST00000703105.1
ENST00000703104.1 [Q9HCI7-2]
C9IZG7
ENST00000434835.2 [Q9HCI7-2]
ENST00000703103.1 [Q9HCI7-2]
ENST00000481989.2 [Q9HCI7-2]
C9IZ03
ENST00000491050.2 [Q9HCI7-2]
A0A8V8TR57
C9J5S2
ENST00000309993.3 [Q9HCI7-1]
Q9HCI7
ENST00000491050.1
ENST00000481989.1
ENST00000473093.1