MOSPD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0090026Biological processpositive regulation of monocyte chemotaxis
GO_0140042Biological processlipid droplet formation
GO_0006935Biological processchemotaxis
GO_0090023Biological processpositive regulation of neutrophil chemotaxis
GO_0140284Cellular componentendoplasmic reticulum-endosome membrane contact site
GO_0012505Cellular componentendomembrane system
GO_0005783Cellular componentendoplasmic reticulum
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0044232Cellular componentorganelle membrane contact site
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0033149Molecular functionFFAT motif binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMOSPD2
Protein nameMotile sperm domain containing 2
Motile sperm domain-containing protein 2
SynonymshCG_15755
DescriptionFUNCTION: Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and endosomes, mitochondria or Golgi through interaction with conventional- and phosphorylated-FFAT-containing organelle-bound proteins . In addition, forms endoplasmic reticulum (ER)-lipid droplets (LDs) contacts through a direct protein-membrane interaction and participates in LDs homeostasis . The attachment mechanism involves an amphipathic helix that has an affinity for lipid packing defects present at the surface of LDs . Promotes migration of primary monocytes and neutrophils, in response to various chemokines . .

AccessionsENST00000497603.2
Q8NHP6
R4GMW5
ENST00000482354.5
ENST00000380492.8 [Q8NHP6-1]
R4GNB6
R4GMN1
ENST00000460386.1