Name | Number of supported studies | Average coverage | |
---|---|---|---|
microglial cell | 11 studies | 34% ± 13% | |
endothelial cell | 9 studies | 24% ± 9% | |
dendritic cell | 8 studies | 25% ± 4% | |
macrophage | 8 studies | 29% ± 12% | |
glutamatergic neuron | 7 studies | 35% ± 20% | |
GABAergic neuron | 7 studies | 32% ± 16% | |
astrocyte | 7 studies | 30% ± 11% | |
plasmacytoid dendritic cell | 6 studies | 20% ± 5% | |
renal alpha-intercalated cell | 5 studies | 50% ± 20% | |
epithelial cell | 5 studies | 27% ± 8% | |
oligodendrocyte precursor cell | 5 studies | 27% ± 8% | |
myeloid cell | 4 studies | 22% ± 5% | |
platelet | 4 studies | 22% ± 5% | |
ciliated cell | 4 studies | 23% ± 6% | |
erythrocyte | 4 studies | 50% ± 18% | |
interneuron | 4 studies | 34% ± 19% | |
ependymal cell | 3 studies | 46% ± 12% | |
megakaryocyte | 3 studies | 43% ± 23% | |
monocyte | 3 studies | 21% ± 6% | |
smooth muscle cell | 3 studies | 19% ± 0% | |
renal principal cell | 3 studies | 42% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 1846.77 | 245 / 245 | 100% | 19.30 | 502 / 502 |
brain | 100% | 1771.02 | 2639 / 2642 | 100% | 18.13 | 704 / 705 |
kidney | 100% | 3417.61 | 89 / 89 | 100% | 23.68 | 897 / 901 |
thymus | 100% | 2262.73 | 653 / 653 | 100% | 17.63 | 602 / 605 |
breast | 100% | 1790.74 | 459 / 459 | 99% | 17.74 | 1112 / 1118 |
esophagus | 100% | 1869.44 | 1445 / 1445 | 99% | 13.92 | 182 / 183 |
lung | 100% | 2928.05 | 578 / 578 | 99% | 13.14 | 1146 / 1155 |
pancreas | 100% | 932.37 | 327 / 328 | 99% | 15.55 | 176 / 178 |
uterus | 100% | 2060.51 | 170 / 170 | 97% | 10.12 | 444 / 459 |
bladder | 100% | 1951.29 | 21 / 21 | 96% | 10.84 | 486 / 504 |
skin | 100% | 2105.10 | 1808 / 1809 | 94% | 17.69 | 445 / 472 |
ovary | 100% | 2327.23 | 180 / 180 | 94% | 8.87 | 405 / 430 |
adrenal gland | 100% | 1739.14 | 258 / 258 | 94% | 7.54 | 216 / 230 |
stomach | 100% | 1346.09 | 359 / 359 | 93% | 9.03 | 267 / 286 |
intestine | 100% | 1820.83 | 966 / 966 | 89% | 8.22 | 467 / 527 |
liver | 100% | 758.13 | 226 / 226 | 61% | 3.83 | 246 / 406 |
adipose | 100% | 1707.32 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2097.95 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 10.26 | 29 / 29 |
spleen | 100% | 1650.19 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 10.16 | 1 / 1 |
muscle | 100% | 1183.32 | 802 / 803 | 0% | 0 | 0 / 0 |
heart | 98% | 1363.94 | 847 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 9.09 | 44 / 45 |
eye | 0% | 0 | 0 / 0 | 68% | 5.71 | 54 / 80 |
peripheral blood | 57% | 759.51 | 526 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0031952 | Biological process | regulation of protein autophosphorylation |
GO_0001934 | Biological process | positive regulation of protein phosphorylation |
GO_0035329 | Biological process | hippo signaling |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0043539 | Molecular function | protein serine/threonine kinase activator activity |
GO_0019900 | Molecular function | kinase binding |
GO_0030295 | Molecular function | protein kinase activator activity |
GO_0019209 | Molecular function | kinase activator activity |
GO_0005515 | Molecular function | protein binding |
GO_0046872 | Molecular function | metal ion binding |
Gene name | MOB1B |
Protein name | MOB kinase activator 1B MOB kinase activator 1B (Mob1 homolog 1A) (Mob1A) (Mob1B) (Mps one binder kinase activator-like 1A) |
Synonyms | MOB4A MOBKL1A |
Description | FUNCTION: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. . |
Accessions | ENST00000396051.2 [Q7L9L4-2] D6RCK3 ENST00000502869.5 ENST00000309395.7 [Q7L9L4-1] Q7L9L4 |