MOB1B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031952Biological processregulation of protein autophosphorylation
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0035329Biological processhippo signaling
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0019900Molecular functionkinase binding
GO_0030295Molecular functionprotein kinase activator activity
GO_0019209Molecular functionkinase activator activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameMOB1B
Protein nameMOB kinase activator 1B
MOB kinase activator 1B (Mob1 homolog 1A) (Mob1A) (Mob1B) (Mps one binder kinase activator-like 1A)
SynonymsMOB4A
MOBKL1A
DescriptionFUNCTION: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. .

AccessionsENST00000396051.2 [Q7L9L4-2]
D6RCK3
ENST00000502869.5
ENST00000309395.7 [Q7L9L4-1]
Q7L9L4