MIXL1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MIXL1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MIXL1 at tissue level.

III. Associated gene sets

GO_0002244Biological processhematopoietic progenitor cell differentiation
GO_0007507Biological processheart development
GO_1901533Biological processnegative regulation of hematopoietic progenitor cell differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0035987Biological processendodermal cell differentiation
GO_2000382Biological processpositive regulation of mesoderm development
GO_0007369Biological processgastrulation
GO_0007492Biological processendoderm development
GO_0042074Biological processcell migration involved in gastrulation
GO_0048565Biological processdigestive tract development
GO_0001706Biological processendoderm formation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding

IV. Literature review

[source]
Gene nameMIXL1
Protein nameHomeobox protein MIXL1 (Homeodomain protein MIX) (hMix) (MIX1 homeobox-like protein 1) (Mix.1 homeobox-like protein)
SynonymsMIXL
DescriptionFUNCTION: Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression (By similarity). .

AccessionsQ9H2W2
ENST00000366810.6 [Q9H2W2-1]
ENST00000542034.5 [Q9H2W2-2]