METTL16 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070475Biological processrRNA base methylation
GO_1905869Biological processnegative regulation of 3'-UTR-mediated mRNA stabilization
GO_0061157Biological processmRNA destabilization
GO_0048024Biological processregulation of mRNA splicing, via spliceosome
GO_0006397Biological processmRNA processing
GO_0010608Biological processpost-transcriptional regulation of gene expression
GO_0006556Biological processS-adenosylmethionine biosynthetic process
GO_0006402Biological processmRNA catabolic process
GO_0120049Biological processsnRNA (adenine-N6)-methylation
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0030629Molecular functionU6 snRNA 3'-end binding
GO_0120048Molecular functionU6 snRNA (adenine-(43)-N(6))-methyltransferase activity
GO_0035613Molecular functionRNA stem-loop binding
GO_0052907Molecular function23S rRNA (adenine(1618)-N(6))-methyltransferase activity
GO_0001734Molecular functionmRNA m(6)A methyltransferase activity
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameMETTL16
Protein nameMethyltransferase 16, N6-methyladenosine
RNA N6-adenosine-methyltransferase METTL16 (Methyltransferase 10 domain-containing protein) (Methyltransferase-like protein 16) (N6-adenosine-methyltransferase METTL16) (EC 2.1.1.348) (U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase) (EC 2.1.1.346)
SynonymsMETT10D
DescriptionFUNCTION: RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts . Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) . In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure . Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase . In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A . In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs . Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA . Specifically binds the 3'-end of the MALAT1 long non-coding RNA . .

AccessionsQ86W50
I3L3W3
K7EKQ8
I3L362
ENST00000263092.11 [Q86W50-1]
ENST00000576976.2
ENST00000576556.5
ENST00000574752.5
ENST00000571298.5
I3L4V1