METTL14 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045664Biological processregulation of neuron differentiation
GO_0007283Biological processspermatogenesis
GO_0006397Biological processmRNA processing
GO_0006402Biological processmRNA catabolic process
GO_1901533Biological processnegative regulation of hematopoietic progenitor cell differentiation
GO_0001510Biological processRNA methylation
GO_0061157Biological processmRNA destabilization
GO_0048255Biological processmRNA stabilization
GO_0021861Biological processforebrain radial glial cell differentiation
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0019827Biological processstem cell population maintenance
GO_0042063Biological processgliogenesis
GO_0016556Biological processmRNA modification
GO_0045727Biological processpositive regulation of translation
GO_0005654Cellular componentnucleoplasm
GO_0036396Cellular componentRNA N6-methyladenosine methyltransferase complex
GO_0005634Cellular componentnucleus
GO_1904047Molecular functionS-adenosyl-L-methionine binding
GO_0003729Molecular functionmRNA binding
GO_0001734Molecular functionmRNA m(6)A methyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMETTL14
Protein nameMethyltransferase 14, N6-adenosine-methyltransferase subunit
N6-adenosine-methyltransferase non-catalytic subunit (Methyltransferase-like protein 14) (hMETTL14)
N6-adenosine-methyltransferase non-catalytic subunit (Methyltransferase-like protein 14)
SynonymsKIAA1627
DescriptionFUNCTION: The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis . In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core . N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing . M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). .

FUNCTION: The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells. .

AccessionsENST00000388822.10
A0A0D9SF88
D6RBL4
D6RD73
ENST00000508801.1
ENST00000626212.2
Q9HCE5
ENST00000506780.2
A0A0D9SFW0
ENST00000628452.2