MEOX1 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	8 studies	25% ± 8%	Explore
vein endothelial cell	5 studies	25% ± 7%	Explore
endothelial cell of vascular tree	3 studies	16% ± 0%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of MEOX1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	2854.46	458 / 459	64%	6.99	719 / 1118
esophagus	91%	642.88	1309 / 1445	48%	2.65	87 / 183
bladder	95%	811.90	20 / 21	38%	2.17	194 / 504
uterus	86%	704.87	146 / 170	46%	5.62	212 / 459
intestine	86%	486.01	830 / 966	42%	2.31	222 / 527
prostate	53%	250.27	129 / 245	75%	4.45	378 / 502
skin	68%	467.51	1229 / 1809	47%	5.23	221 / 472
stomach	50%	234.90	179 / 359	54%	2.96	154 / 286
adipose	100%	3281.27	1200 / 1204	0%	0	0 / 0
heart	99%	1244.90	852 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	13.48	28 / 29
muscle	89%	485.06	711 / 803	0%	0	0 / 0
pancreas	9%	25.20	30 / 328	79%	8.60	140 / 178
ovary	12%	95.14	21 / 180	76%	20.60	325 / 430
spleen	86%	1066.61	207 / 241	0%	0	0 / 0
thymus	43%	186.69	284 / 653	42%	2.51	256 / 605
tonsil	0%	0	0 / 0	84%	8.15	38 / 45
blood vessel	61%	412.52	819 / 1335	0%	0	0 / 0
lung	13%	58.70	78 / 578	35%	2.61	405 / 1155
kidney	1%	3.65	1 / 89	11%	0.47	99 / 901
adrenal gland	2%	5.31	5 / 258	10%	0.86	23 / 230
liver	0%	0	0 / 226	12%	0.58	47 / 406
eye	0%	0	0 / 0	4%	0.15	3 / 80
peripheral blood	2%	5.30	16 / 929	0%	0	0 / 0
brain	0%	0	0 / 2642	1%	0.52	7 / 705
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0060218	Biological process	hematopoietic stem cell differentiation
GO_0061056	Biological process	sclerotome development
GO_0001757	Biological process	somite specification
GO_0061053	Biological process	somite development
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0000785	Cellular component	chromatin
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0005515	Molecular function	protein binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0071837	Molecular function	HMG box domain binding
GO_0043565	Molecular function	sequence-specific DNA binding
GO_0003682	Molecular function	chromatin binding

Gene name	MEOX1
Protein name	Homeobox protein MOX-1 (Mesenchyme homeobox 1)
Synonyms	MOX1
Description	FUNCTION: Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints . Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. .
Accessions	ENST00000393661.2 [P50221-3] ENST00000549132.2 [P50221-2] ENST00000318579.9 [P50221-1] P50221

MEOX1 report