MED8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051123Biological processRNA polymerase II preinitiation complex assembly
GO_0016567Biological processprotein ubiquitination
GO_0060261Biological processpositive regulation of transcription initiation by RNA polymerase II
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000151Cellular componentubiquitin ligase complex
GO_0016592Cellular componentmediator complex
GO_0005654Cellular componentnucleoplasm
GO_0070847Cellular componentcore mediator complex
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0005515Molecular functionprotein binding
GO_0003712Molecular functiontranscription coregulator activity

IV. Literature review

[source]
Gene nameMED8
Protein nameMediator of RNA polymerase II transcription subunit 8 (Activator-recruited cofactor 32 kDa component) (ARC32) (Mediator complex subunit 8)
Alternative protein MED8
Synonyms
DescriptionFUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.

AccessionsENST00000290663.10 [Q96G25-2]
Q96G25
ENST00000372457.9 [Q96G25-1]
L8E9D9
ENST00000372455.4 [Q96G25-3]