Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 7 studies | 25% ± 9% | |
glutamatergic neuron | 6 studies | 44% ± 26% | |
GABAergic neuron | 6 studies | 37% ± 19% | |
epithelial cell | 5 studies | 27% ± 8% | |
astrocyte | 5 studies | 24% ± 7% | |
oligodendrocyte | 5 studies | 24% ± 5% | |
macrophage | 5 studies | 22% ± 5% | |
B cell | 4 studies | 22% ± 2% | |
microglial cell | 4 studies | 20% ± 2% | |
oligodendrocyte precursor cell | 4 studies | 25% ± 6% | |
endothelial cell of lymphatic vessel | 4 studies | 23% ± 3% | |
interneuron | 4 studies | 42% ± 22% | |
ciliated cell | 3 studies | 19% ± 1% | |
fibroblast | 3 studies | 20% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2327.18 | 1445 / 1445 | 100% | 20.98 | 183 / 183 |
lung | 100% | 2523.84 | 578 / 578 | 100% | 15.46 | 1154 / 1155 |
intestine | 100% | 2771.38 | 966 / 966 | 100% | 15.09 | 526 / 527 |
stomach | 100% | 2273.65 | 359 / 359 | 100% | 16.33 | 285 / 286 |
breast | 100% | 2967.70 | 459 / 459 | 100% | 25.26 | 1113 / 1118 |
prostate | 100% | 2918.06 | 245 / 245 | 99% | 21.11 | 499 / 502 |
ovary | 100% | 3394.61 | 180 / 180 | 99% | 12.26 | 427 / 430 |
thymus | 100% | 3550.76 | 653 / 653 | 99% | 18.04 | 600 / 605 |
bladder | 100% | 2541.00 | 21 / 21 | 99% | 12.81 | 499 / 504 |
uterus | 100% | 3467.68 | 170 / 170 | 99% | 14.00 | 454 / 459 |
pancreas | 100% | 2047.17 | 328 / 328 | 99% | 12.55 | 176 / 178 |
brain | 98% | 1866.62 | 2590 / 2642 | 100% | 14.22 | 705 / 705 |
adrenal gland | 100% | 2661.45 | 258 / 258 | 98% | 10.35 | 225 / 230 |
kidney | 100% | 1892.12 | 89 / 89 | 98% | 14.17 | 881 / 901 |
skin | 100% | 2906.76 | 1809 / 1809 | 95% | 13.01 | 449 / 472 |
liver | 100% | 1234.97 | 226 / 226 | 77% | 5.80 | 314 / 406 |
adipose | 100% | 2530.87 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2478.16 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 3332.80 | 241 / 241 | 0% | 0 | 0 / 0 |
muscle | 100% | 1284.09 | 801 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 14.08 | 44 / 45 |
heart | 98% | 1170.75 | 840 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 97% | 12.37 | 28 / 29 |
eye | 0% | 0 | 0 / 0 | 81% | 7.09 | 65 / 80 |
peripheral blood | 81% | 1457.97 | 754 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0051123 | Biological process | RNA polymerase II preinitiation complex assembly |
GO_0010628 | Biological process | positive regulation of gene expression |
GO_0060261 | Biological process | positive regulation of transcription initiation by RNA polymerase II |
GO_0006367 | Biological process | transcription initiation at RNA polymerase II promoter |
GO_2000409 | Biological process | positive regulation of T cell extravasation |
GO_0006355 | Biological process | regulation of DNA-templated transcription |
GO_0032968 | Biological process | positive regulation of transcription elongation by RNA polymerase II |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0016592 | Cellular component | mediator complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0070847 | Cellular component | core mediator complex |
GO_0005667 | Cellular component | transcription regulator complex |
GO_0005634 | Cellular component | nucleus |
GO_0003713 | Molecular function | transcription coactivator activity |
GO_0005515 | Molecular function | protein binding |
Gene name | MED23 |
Protein name | Mediator complex subunit MED23 variant MED23_i10 Mediator complex subunit MED23 variant MED23_i7 Mediator complex subunit MED23 variant MED23_i13 Mediator of RNA polymerase II transcription subunit 23 (Mediator complex subunit 23) Mediator complex subunit MED23 variant MED23_i11 Mediator complex subunit MED23 variant MED23_i12 Mediator of RNA polymerase II transcription subunit 23 (Activator-recruited cofactor 130 kDa component) (ARC130) (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) (Protein sur-2 homolog) (hSur-2) (Transcriptional coactivator CRSP130) (Vitamin D3 receptor-interacting protein complex 130 kDa component) (DRIP130) Mediator complex subunit MED23 variant MED23_i9 |
Synonyms | SUR2 DRIP130 ARC130 KIAA1216 CRSP3 |
Description | FUNCTION: Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. . |
Accessions | Q9ULK4 ENST00000368060.7 [Q9ULK4-5] ENST00000539158.1 [Q9ULK4-6] B9TX59 ENST00000368053.8 [Q9ULK4-2] ENST00000354577.8 [Q9ULK4-3] B9TX51 B9TX53 Q5JWT2 B9TX56 ENST00000368058.5 ENST00000368068.8 [Q9ULK4-1] B9TX49 Q05DL5 B9TX52 B9TX50 B9TX54 B9TX60 B9TX57 B9TX58 |