Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 7 studies | 25% ± 9% | |
| glutamatergic neuron | 6 studies | 44% ± 26% | |
| GABAergic neuron | 6 studies | 37% ± 19% | |
| epithelial cell | 5 studies | 27% ± 8% | |
| astrocyte | 5 studies | 24% ± 7% | |
| oligodendrocyte | 5 studies | 24% ± 5% | |
| macrophage | 5 studies | 22% ± 5% | |
| B cell | 4 studies | 22% ± 2% | |
| microglial cell | 4 studies | 20% ± 2% | |
| oligodendrocyte precursor cell | 4 studies | 25% ± 6% | |
| endothelial cell of lymphatic vessel | 4 studies | 23% ± 3% | |
| interneuron | 4 studies | 42% ± 22% | |
| ciliated cell | 3 studies | 19% ± 1% | |
| fibroblast | 3 studies | 20% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2327.18 | 1445 / 1445 | 100% | 20.98 | 183 / 183 |
| lung | 100% | 2523.84 | 578 / 578 | 100% | 15.46 | 1154 / 1155 |
| intestine | 100% | 2771.38 | 966 / 966 | 100% | 15.09 | 526 / 527 |
| stomach | 100% | 2273.65 | 359 / 359 | 100% | 16.33 | 285 / 286 |
| breast | 100% | 2967.70 | 459 / 459 | 100% | 25.26 | 1113 / 1118 |
| prostate | 100% | 2918.06 | 245 / 245 | 99% | 21.11 | 499 / 502 |
| ovary | 100% | 3394.61 | 180 / 180 | 99% | 12.26 | 427 / 430 |
| thymus | 100% | 3550.76 | 653 / 653 | 99% | 18.04 | 600 / 605 |
| bladder | 100% | 2541.00 | 21 / 21 | 99% | 12.81 | 499 / 504 |
| uterus | 100% | 3467.68 | 170 / 170 | 99% | 14.00 | 454 / 459 |
| pancreas | 100% | 2047.17 | 328 / 328 | 99% | 12.55 | 176 / 178 |
| brain | 98% | 1866.62 | 2590 / 2642 | 100% | 14.22 | 705 / 705 |
| adrenal gland | 100% | 2661.45 | 258 / 258 | 98% | 10.35 | 225 / 230 |
| kidney | 100% | 1892.12 | 89 / 89 | 98% | 14.17 | 881 / 901 |
| skin | 100% | 2906.76 | 1809 / 1809 | 95% | 13.01 | 449 / 472 |
| liver | 100% | 1234.97 | 226 / 226 | 77% | 5.80 | 314 / 406 |
| adipose | 100% | 2530.87 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2478.16 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 100% | 3332.80 | 241 / 241 | 0% | 0 | 0 / 0 |
| muscle | 100% | 1284.09 | 801 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 14.08 | 44 / 45 |
| heart | 98% | 1170.75 | 840 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 12.37 | 28 / 29 |
| eye | 0% | 0 | 0 / 0 | 81% | 7.09 | 65 / 80 |
| peripheral blood | 81% | 1457.97 | 754 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0051123 | Biological process | RNA polymerase II preinitiation complex assembly |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0060261 | Biological process | positive regulation of transcription initiation by RNA polymerase II |
| GO_0006367 | Biological process | transcription initiation at RNA polymerase II promoter |
| GO_2000409 | Biological process | positive regulation of T cell extravasation |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0032968 | Biological process | positive regulation of transcription elongation by RNA polymerase II |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0016592 | Cellular component | mediator complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0070847 | Cellular component | core mediator complex |
| GO_0005667 | Cellular component | transcription regulator complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0003713 | Molecular function | transcription coactivator activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | MED23 |
| Protein name | Mediator complex subunit MED23 variant MED23_i10 Mediator complex subunit MED23 variant MED23_i7 Mediator complex subunit MED23 variant MED23_i13 Mediator of RNA polymerase II transcription subunit 23 (Mediator complex subunit 23) Mediator complex subunit MED23 variant MED23_i11 Mediator complex subunit MED23 variant MED23_i12 Mediator of RNA polymerase II transcription subunit 23 (Activator-recruited cofactor 130 kDa component) (ARC130) (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) (Protein sur-2 homolog) (hSur-2) (Transcriptional coactivator CRSP130) (Vitamin D3 receptor-interacting protein complex 130 kDa component) (DRIP130) Mediator complex subunit MED23 variant MED23_i9 |
| Synonyms | SUR2 DRIP130 ARC130 KIAA1216 CRSP3 |
| Description | FUNCTION: Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. . |
| Accessions | Q9ULK4 ENST00000368060.7 [Q9ULK4-5] ENST00000539158.1 [Q9ULK4-6] B9TX59 ENST00000368053.8 [Q9ULK4-2] ENST00000354577.8 [Q9ULK4-3] B9TX51 B9TX53 Q5JWT2 B9TX56 ENST00000368058.5 ENST00000368068.8 [Q9ULK4-1] B9TX49 Q05DL5 B9TX52 B9TX50 B9TX54 B9TX60 B9TX57 B9TX58 |