MED23 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051123Biological processRNA polymerase II preinitiation complex assembly
GO_0010628Biological processpositive regulation of gene expression
GO_0060261Biological processpositive regulation of transcription initiation by RNA polymerase II
GO_0006367Biological processtranscription initiation at RNA polymerase II promoter
GO_2000409Biological processpositive regulation of T cell extravasation
GO_0006355Biological processregulation of DNA-templated transcription
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0016592Cellular componentmediator complex
GO_0005654Cellular componentnucleoplasm
GO_0070847Cellular componentcore mediator complex
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMED23
Protein nameMediator complex subunit MED23 variant MED23_i10
Mediator complex subunit MED23 variant MED23_i7
Mediator complex subunit MED23 variant MED23_i13
Mediator of RNA polymerase II transcription subunit 23 (Mediator complex subunit 23)
Mediator complex subunit MED23 variant MED23_i11
Mediator complex subunit MED23 variant MED23_i12
Mediator of RNA polymerase II transcription subunit 23 (Activator-recruited cofactor 130 kDa component) (ARC130) (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) (Protein sur-2 homolog) (hSur-2) (Transcriptional coactivator CRSP130) (Vitamin D3 receptor-interacting protein complex 130 kDa component) (DRIP130)
Mediator complex subunit MED23 variant MED23_i9
SynonymsSUR2
DRIP130
ARC130
KIAA1216
CRSP3
DescriptionFUNCTION: Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. .

AccessionsQ9ULK4
ENST00000368060.7 [Q9ULK4-5]
ENST00000539158.1 [Q9ULK4-6]
B9TX59
ENST00000368053.8 [Q9ULK4-2]
ENST00000354577.8 [Q9ULK4-3]
B9TX51
B9TX53
Q5JWT2
B9TX56
ENST00000368058.5
ENST00000368068.8 [Q9ULK4-1]
B9TX49
Q05DL5
B9TX52
B9TX50
B9TX54
B9TX60
B9TX57
B9TX58