MED21 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051123Biological processRNA polymerase II preinitiation complex assembly
GO_0016567Biological processprotein ubiquitination
GO_0001824Biological processblastocyst development
GO_0060261Biological processpositive regulation of transcription initiation by RNA polymerase II
GO_0035019Biological processsomatic stem cell population maintenance
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000151Cellular componentubiquitin ligase complex
GO_0016592Cellular componentmediator complex
GO_0005654Cellular componentnucleoplasm
GO_0070847Cellular componentcore mediator complex
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0003899Molecular functionDNA-directed 5'-3' RNA polymerase activity

IV. Literature review

[source]
Gene nameMED21
Protein nameMediator complex subunit 21
Mediator of RNA polymerase II transcription subunit 21
Mediator of RNA polymerase II transcription subunit 21 (Mediator complex subunit 21) (RNA polymerase II holoenzyme component SRB7) (RNAPII complex component SRB7) (hSrb7)
SynonymsSURB7
SRB7
DescriptionFUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. .

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. .

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. .

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. .

AccessionsENST00000546323.5
F5H872
Q13503
A0A0S2Z545
A0A024RAW0
F5GZQ1
ENST00000536711.5
ENST00000282892.4