MED17 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0051123Biological processRNA polymerase II preinitiation complex assembly
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_0060261Biological processpositive regulation of transcription initiation by RNA polymerase II
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006367Biological processtranscription initiation at RNA polymerase II promoter
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0035019Biological processsomatic stem cell population maintenance
GO_0000151Cellular componentubiquitin ligase complex
GO_0016592Cellular componentmediator complex
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0070847Cellular componentcore mediator complex
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0046966Molecular functionnuclear thyroid hormone receptor binding
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0003712Molecular functiontranscription coregulator activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0042809Molecular functionnuclear vitamin D receptor binding
GO_0030374Molecular functionnuclear receptor coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMED17
Protein nameCofactor required for Sp1 transcriptional activation subunit 6
Mediator of RNA polymerase II transcription subunit 17 (Mediator complex subunit 17)
Mediator complex subunit 17
Mediator of RNA polymerase II transcription subunit 17 (Activator-recruited cofactor 77 kDa component) (ARC77) (Cofactor required for Sp1 transcriptional activation subunit 6) (CRSP complex subunit 6) (Mediator complex subunit 17) (Thyroid hormone receptor-associated protein complex 80 kDa component) (Trap80) (Transcriptional coactivator CRSP77) (Vitamin D3 receptor-interacting protein complex 80 kDa component) (DRIP80)
SynonymsTRAP80
DRIP80
CRSP6
ARC77
DRIP77
DescriptionFUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. .

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. .

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. .

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. .

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. .

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. .

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. .

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. .

AccessionsA0A1W2PS69
Q9NVC6
A0A1W2PRS0
A0A1W2PRX4
ENST00000638487.1
ENST00000251871.9 [Q9NVC6-1]
ENST00000640473.1
ENST00000528786.2
ENST00000533359.5
E9PKQ4
ENST00000638294.1
ENST00000639596.1
A0A1W2PS27
B4DSE1
ENST00000533133.6
ENST00000638518.1
A0A1W2PPJ7
ENST00000639457.1
E9PM72
ENST00000639724.1
A0A1W2PQ48
A0A1W2PR99
ENST00000640077.1
A0A1W2PPC8
A0A1W2PQE4
A0A1W2PNW7
ENST00000640027.1
ENST00000640451.1
ENST00000639189.1
A0A384NYG5
ENST00000638790.1
E9PJZ4
A0A1W2PPP8
ENST00000639523.1
ENST00000640521.1
A0A1W2PNF3