MCRS1 | OmnibusX

Name	Number of supported studies	Average coverage
natural killer cell	6 studies	18% ± 2%	Explore
epithelial cell	5 studies	29% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	17% ± 2%	Explore
non-classical monocyte	3 studies	23% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	20% ± 2%	Explore
CD8-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore
glutamatergic neuron	3 studies	26% ± 8%	Explore
dendritic cell	3 studies	29% ± 2%	Explore
plasmacytoid dendritic cell	3 studies	21% ± 3%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MCRS1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3049.01	1445 / 1445	100%	47.31	183 / 183
liver	100%	1567.95	226 / 226	100%	39.81	406 / 406
ovary	100%	2402.35	180 / 180	100%	60.96	430 / 430
pancreas	100%	1981.53	328 / 328	100%	55.81	178 / 178
skin	100%	2704.71	1809 / 1809	100%	62.08	472 / 472
thymus	100%	4124.07	653 / 653	100%	76.33	605 / 605
uterus	100%	3163.00	170 / 170	100%	71.01	459 / 459
brain	100%	2477.79	2639 / 2642	100%	71.38	705 / 705
kidney	100%	3321.78	89 / 89	100%	53.58	898 / 901
lung	100%	2564.26	578 / 578	100%	58.15	1151 / 1155
intestine	100%	3149.11	966 / 966	100%	69.28	525 / 527
breast	100%	2657.11	459 / 459	100%	57.82	1113 / 1118
prostate	100%	3555.38	245 / 245	99%	59.10	499 / 502
stomach	100%	2583.64	359 / 359	99%	58.87	284 / 286
adrenal gland	100%	2925.53	258 / 258	99%	49.50	228 / 230
bladder	100%	2947.48	21 / 21	99%	67.20	499 / 504
adipose	100%	2349.78	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	61.61	80 / 80
lymph node	0%	0	0 / 0	100%	80.18	29 / 29
muscle	100%	2727.45	803 / 803	0%	0	0 / 0
spleen	100%	3524.47	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	66.62	45 / 45
ureter	0%	0	0 / 0	100%	27.06	1 / 1
blood vessel	100%	2531.94	1334 / 1335	0%	0	0 / 0
heart	100%	3979.56	860 / 861	0%	0	0 / 0
peripheral blood	98%	2230.60	906 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006281	Biological process	DNA repair
GO_0045995	Biological process	regulation of embryonic development
GO_0045739	Biological process	positive regulation of DNA repair
GO_0006282	Biological process	regulation of DNA repair
GO_0060382	Biological process	regulation of DNA strand elongation
GO_1904507	Biological process	positive regulation of telomere maintenance in response to DNA damage
GO_0006338	Biological process	chromatin remodeling
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0036211	Biological process	protein modification process
GO_0000723	Biological process	telomere maintenance
GO_0033044	Biological process	regulation of chromosome organization
GO_0006310	Biological process	DNA recombination
GO_0006275	Biological process	regulation of DNA replication
GO_1904751	Biological process	positive regulation of protein localization to nucleolus
GO_0051726	Biological process	regulation of cell cycle
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005730	Cellular component	nucleolus
GO_0044545	Cellular component	NSL complex
GO_0071339	Cellular component	MLL1 complex
GO_0043204	Cellular component	perikaryon
GO_0005654	Cellular component	nucleoplasm
GO_0030425	Cellular component	dendrite
GO_0005737	Cellular component	cytoplasm
GO_0000123	Cellular component	histone acetyltransferase complex
GO_0031011	Cellular component	Ino80 complex
GO_0005634	Cellular component	nucleus
GO_0034046	Molecular function	poly(G) binding
GO_0008266	Molecular function	poly(U) RNA binding
GO_0002151	Molecular function	G-quadruplex RNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	MCRS1
Protein name	Microspherule protein 1 Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2) Alternative protein MCRS1
Synonyms	MSP58 INO80Q
Description	FUNCTION: Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus . As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues . Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity . Binds to G-quadruplex structures in mRNA . Binds to RNA homomer poly(G) and poly(U) . .
Accessions	L8E8H6 ENST00000553173.5 F8VZC2 ENST00000548646.5 F8W0I9 H0YI67 ENST00000357123.8 [Q96EZ8-2] ENST00000546244.5 [Q96EZ8-4] F8VP44 ENST00000549528.1 ENST00000548602.5 ENST00000551598.5 ENST00000548334.5 F8W126 F8VVA6 Q96EZ8 ENST00000548596.5 ENST00000550165.5 [Q96EZ8-1] ENST00000343810.9 [Q96EZ8-1] H0YIA0

MCRS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review