MCM9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032508Biological processDNA duplex unwinding
GO_0006974Biological processDNA damage response
GO_0006260Biological processDNA replication
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0036298Biological processrecombinational interstrand cross-link repair
GO_0070716Biological processmismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication
GO_0071168Biological processprotein localization to chromatin
GO_0007292Biological processfemale gamete generation
GO_0097362Cellular componentMCM8-MCM9 complex
GO_0042555Cellular componentMCM complex
GO_0005694Cellular componentchromosome
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0032407Molecular functionMutSalpha complex binding
GO_0003682Molecular functionchromatin binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0003678Molecular functionDNA helicase activity
GO_0017116Molecular functionsingle-stranded DNA helicase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0032408Molecular functionMutSbeta complex binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0032406Molecular functionMutLbeta complex binding

IV. Literature review

[source]
Gene nameMCM9
Protein nameMinichromosome maintenance 9 homologous recombination repair factor
DNA helicase MCM9 (hMCM9) (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9)
Minichromosome maintenance complex component 9 isoform 2
Minichromosome maintenance 9 homologous recombination repair factor (EC 3.6.4.12)
DNA helicase MCM9 (EC 3.6.4.12)
Minichromosome maintenance 9 homologous recombination repair factor variant (EC 3.6.4.12)
DNA helicase (EC 3.6.4.12)
SynonymsMCMDC1
hCG_2030528
C6orf61
DescriptionFUNCTION: Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) . Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity . Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs . Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand . In addition, recruits MLH1, a component of the MMR complex, to chromatin . The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression . Probably by regulating HR, plays a key role during gametogenesis (By similarity). .

AccessionsENST00000425154.6
A0A482KL27
A0A482KD00
ENST00000458674.2
A0A4D6GKE3
A0A4D6GL99
ENST00000619706.5 [Q9NXL9-1]
A0A0S2Z600
Q9NXL9
ENST00000316316.10 [Q9NXL9-1]
ENST00000316068.7 [Q9NXL9-3]
A0A4D6GKF8
A0A0S2Z662
A0A4D6GKC9
D6RHY8
A0A4D6GNL0
ENST00000505446.1
D6RE85
H0Y6M9