Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 7 studies | 22% ± 5% | |
astrocyte | 5 studies | 32% ± 12% | |
microglial cell | 5 studies | 25% ± 7% | |
oligodendrocyte | 5 studies | 25% ± 6% | |
macrophage | 5 studies | 23% ± 4% | |
adipocyte | 4 studies | 20% ± 4% | |
GABAergic neuron | 4 studies | 29% ± 8% | |
glutamatergic neuron | 4 studies | 34% ± 9% | |
oligodendrocyte precursor cell | 4 studies | 27% ± 8% | |
endothelial cell of lymphatic vessel | 4 studies | 19% ± 4% | |
monocyte | 3 studies | 20% ± 1% | |
interneuron | 3 studies | 30% ± 14% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 4 studies | 35% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 887.00 | 1445 / 1445 | 100% | 4.93 | 183 / 183 |
lung | 100% | 924.11 | 577 / 578 | 100% | 4.34 | 1152 / 1155 |
breast | 100% | 1218.39 | 459 / 459 | 99% | 6.23 | 1111 / 1118 |
thymus | 100% | 1411.46 | 653 / 653 | 99% | 4.32 | 597 / 605 |
pancreas | 100% | 627.47 | 327 / 328 | 99% | 3.30 | 176 / 178 |
intestine | 100% | 883.35 | 966 / 966 | 98% | 3.47 | 518 / 527 |
uterus | 100% | 1006.64 | 170 / 170 | 98% | 4.17 | 451 / 459 |
bladder | 100% | 1008.86 | 21 / 21 | 98% | 3.71 | 494 / 504 |
stomach | 100% | 672.69 | 359 / 359 | 98% | 3.46 | 280 / 286 |
brain | 98% | 382.91 | 2582 / 2642 | 99% | 3.27 | 701 / 705 |
prostate | 100% | 1129.15 | 245 / 245 | 97% | 3.86 | 486 / 502 |
ovary | 100% | 790.03 | 180 / 180 | 95% | 2.77 | 407 / 430 |
kidney | 100% | 870.42 | 89 / 89 | 94% | 3.34 | 851 / 901 |
skin | 100% | 1040.58 | 1808 / 1809 | 91% | 2.86 | 430 / 472 |
adrenal gland | 100% | 831.77 | 258 / 258 | 88% | 2.14 | 202 / 230 |
liver | 100% | 447.15 | 226 / 226 | 74% | 1.63 | 302 / 406 |
adipose | 100% | 962.72 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 859.45 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 1113.41 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 4.00 | 45 / 45 |
heart | 97% | 374.83 | 833 / 861 | 0% | 0 | 0 / 0 |
muscle | 94% | 289.39 | 754 / 803 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 93% | 3.23 | 27 / 29 |
peripheral blood | 91% | 550.71 | 849 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 71% | 1.92 | 57 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0032508 | Biological process | DNA duplex unwinding |
GO_0006974 | Biological process | DNA damage response |
GO_0006260 | Biological process | DNA replication |
GO_0000724 | Biological process | double-strand break repair via homologous recombination |
GO_0036298 | Biological process | recombinational interstrand cross-link repair |
GO_0070716 | Biological process | mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication |
GO_0071168 | Biological process | protein localization to chromatin |
GO_0007292 | Biological process | female gamete generation |
GO_0097362 | Cellular component | MCM8-MCM9 complex |
GO_0042555 | Cellular component | MCM complex |
GO_0005694 | Cellular component | chromosome |
GO_0005634 | Cellular component | nucleus |
GO_0019899 | Molecular function | enzyme binding |
GO_0032407 | Molecular function | MutSalpha complex binding |
GO_0003682 | Molecular function | chromatin binding |
GO_0003697 | Molecular function | single-stranded DNA binding |
GO_0044877 | Molecular function | protein-containing complex binding |
GO_0003678 | Molecular function | DNA helicase activity |
GO_0017116 | Molecular function | single-stranded DNA helicase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
GO_0032408 | Molecular function | MutSbeta complex binding |
GO_0016887 | Molecular function | ATP hydrolysis activity |
GO_0032406 | Molecular function | MutLbeta complex binding |
Gene name | MCM9 |
Protein name | Minichromosome maintenance 9 homologous recombination repair factor DNA helicase MCM9 (hMCM9) (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9) Minichromosome maintenance complex component 9 isoform 2 Minichromosome maintenance 9 homologous recombination repair factor (EC 3.6.4.12) DNA helicase MCM9 (EC 3.6.4.12) Minichromosome maintenance 9 homologous recombination repair factor variant (EC 3.6.4.12) DNA helicase (EC 3.6.4.12) |
Synonyms | MCMDC1 hCG_2030528 C6orf61 |
Description | FUNCTION: Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) . Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity . Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs . Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand . In addition, recruits MLH1, a component of the MMR complex, to chromatin . The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression . Probably by regulating HR, plays a key role during gametogenesis (By similarity). . |
Accessions | ENST00000425154.6 A0A482KL27 A0A482KD00 ENST00000458674.2 A0A4D6GKE3 A0A4D6GL99 ENST00000619706.5 [Q9NXL9-1] A0A0S2Z600 Q9NXL9 ENST00000316316.10 [Q9NXL9-1] ENST00000316068.7 [Q9NXL9-3] A0A4D6GKF8 A0A0S2Z662 A0A4D6GKC9 D6RHY8 A0A4D6GNL0 ENST00000505446.1 D6RE85 H0Y6M9 |