MCM3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006268Biological processDNA unwinding involved in DNA replication
GO_0000727Biological processdouble-strand break repair via break-induced replication
GO_0006270Biological processDNA replication initiation
GO_0030174Biological processregulation of DNA-templated DNA replication initiation
GO_0006271Biological processDNA strand elongation involved in DNA replication
GO_1902975Biological processmitotic DNA replication initiation
GO_0005730Cellular componentnucleolus
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005813Cellular componentcentrosome
GO_0005658Cellular componentalpha DNA polymerase:primase complex
GO_0005654Cellular componentnucleoplasm
GO_0042555Cellular componentMCM complex
GO_0071162Cellular componentCMG complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0017116Molecular functionsingle-stranded DNA helicase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameMCM3
Protein nameMinichromosome maintenance complex component 3
DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)
DNA replication licensing factor MCM3 (EC 3.6.4.12)
Synonyms
DescriptionFUNCTION: Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built . The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity . Required for the entry in S phase and for cell division (Probable). .

FUNCTION: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. .

FUNCTION: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. .

FUNCTION: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. .

FUNCTION: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. .

AccessionsENST00000419835.8
A0A499FHX9
ENST00000229854.12
A0A0S2Z492
Q7Z6P5
P25205
ENST00000421471.1
A0A0S2Z4T1
J3KQ69
ENST00000616552.4 [P25205-2]
ENST00000596288.7 [P25205-1]