MARK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030010Biological processestablishment of cell polarity
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0071963Biological processestablishment or maintenance of cell polarity regulating cell shape
GO_0061564Biological processaxon development
GO_1904526Biological processregulation of microtubule binding
GO_0010976Biological processpositive regulation of neuron projection development
GO_0051493Biological processregulation of cytoskeleton organization
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0001764Biological processneuron migration
GO_0032147Biological processactivation of protein kinase activity
GO_0035556Biological processintracellular signal transduction
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0051646Biological processmitochondrion localization
GO_0000422Biological processautophagy of mitochondrion
GO_0070507Biological processregulation of microtubule cytoskeleton organization
GO_0016055Biological processWnt signaling pathway
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0045197Biological processestablishment or maintenance of epithelial cell apical/basal polarity
GO_0050770Biological processregulation of axonogenesis
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0097427Cellular componentmicrotubule bundle
GO_0005884Cellular componentactin filament
GO_0030425Cellular componentdendrite
GO_0016328Cellular componentlateral plasma membrane
GO_0005737Cellular componentcytoplasm
GO_0106310Molecular functionprotein serine kinase activity
GO_0008289Molecular functionlipid binding
GO_0045296Molecular functioncadherin binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0000287Molecular functionmagnesium ion binding
GO_0030295Molecular functionprotein kinase activator activity
GO_0050321Molecular functiontau-protein kinase activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0048156Molecular functiontau protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMARK2
Protein nameSerine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b)
non-specific serine/threonine protein kinase (EC 2.7.11.1)
Microtubule affinity regulating kinase 2
SynonymsEMK1
DescriptionFUNCTION: Serine/threonine-protein kinase . Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU . Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. .

AccessionsENST00000540169.5
A0A7I2YQR3
ENST00000543220.5
ENST00000679216.1
A0AA34QVG3
ENST00000402010.8 [Q7KZI7-1]
ENST00000707173.1
ENST00000502399.7
E7ETY4
ENST00000508192.5 [Q7KZI7-16]
F5H4F6
F5H4J8
F5H6N2
ENST00000408948.7 [Q7KZI7-13]
ENST00000513765.7 [Q7KZI7-8]
ENST00000361128.9 [Q7KZI7-5]
ENST00000425897.3
ENST00000512060.1
Q7KZI7
ENST00000677303.1
A0A1B0GXH6
E9PC69
ENST00000350490.11 [Q7KZI7-15]
A0A0A0MRU9
A0A7I2V3R3
A0A7I2YQF3
ENST00000509502.6 [Q7KZI7-14]
ENST00000543674.1
ENST00000677688.1
ENST00000377810.8