Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 12 studies | 27% ± 11% | |
| astrocyte | 11 studies | 33% ± 16% | |
| oligodendrocyte | 11 studies | 29% ± 11% | |
| fibroblast | 9 studies | 23% ± 7% | |
| adipocyte | 8 studies | 27% ± 10% | |
| oligodendrocyte precursor cell | 8 studies | 31% ± 14% | |
| epithelial cell of proximal tubule | 7 studies | 30% ± 10% | |
| microglial cell | 7 studies | 24% ± 8% | |
| macrophage | 7 studies | 30% ± 8% | |
| GABAergic neuron | 6 studies | 34% ± 18% | |
| kidney loop of Henle epithelial cell | 6 studies | 22% ± 5% | |
| Mueller cell | 6 studies | 31% ± 7% | |
| epithelial cell | 5 studies | 39% ± 12% | |
| cardiac muscle cell | 5 studies | 31% ± 4% | |
| type I pneumocyte | 5 studies | 19% ± 4% | |
| B cell | 4 studies | 19% ± 3% | |
| retinal pigment epithelial cell | 4 studies | 45% ± 16% | |
| abnormal cell | 4 studies | 28% ± 11% | |
| type II pneumocyte | 4 studies | 22% ± 4% | |
| glutamatergic neuron | 4 studies | 50% ± 18% | |
| platelet | 4 studies | 25% ± 2% | |
| interneuron | 4 studies | 38% ± 21% | |
| neuron | 4 studies | 37% ± 20% | |
| memory B cell | 4 studies | 20% ± 1% | |
| amacrine cell | 3 studies | 25% ± 7% | |
| retinal cone cell | 3 studies | 23% ± 4% | |
| hepatocyte | 3 studies | 26% ± 7% | |
| monocyte | 3 studies | 19% ± 3% | |
| ciliated cell | 3 studies | 20% ± 3% | |
| endothelial cell of lymphatic vessel | 3 studies | 22% ± 2% | |
| basal cell | 3 studies | 39% ± 15% | |
| pericyte | 3 studies | 19% ± 3% | |
| smooth muscle cell | 3 studies | 22% ± 5% | |
| kidney distal convoluted tubule epithelial cell | 3 studies | 21% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 100% | 1748.21 | 89 / 89 | 100% | 27.87 | 901 / 901 |
| liver | 100% | 820.14 | 226 / 226 | 100% | 29.15 | 406 / 406 |
| prostate | 100% | 1011.05 | 245 / 245 | 100% | 34.01 | 502 / 502 |
| brain | 100% | 966.61 | 2642 / 2642 | 100% | 26.47 | 704 / 705 |
| thymus | 100% | 1098.31 | 653 / 653 | 100% | 23.94 | 604 / 605 |
| breast | 100% | 885.85 | 459 / 459 | 100% | 27.49 | 1115 / 1118 |
| pancreas | 100% | 744.19 | 327 / 328 | 100% | 17.34 | 178 / 178 |
| adrenal gland | 100% | 1893.47 | 258 / 258 | 99% | 21.75 | 228 / 230 |
| esophagus | 100% | 778.56 | 1445 / 1445 | 99% | 14.75 | 181 / 183 |
| bladder | 100% | 794.29 | 21 / 21 | 98% | 15.65 | 496 / 504 |
| lung | 99% | 646.09 | 571 / 578 | 99% | 20.95 | 1140 / 1155 |
| intestine | 100% | 746.79 | 966 / 966 | 97% | 14.29 | 512 / 527 |
| skin | 100% | 908.04 | 1807 / 1809 | 97% | 25.26 | 459 / 472 |
| stomach | 99% | 523.30 | 357 / 359 | 97% | 13.93 | 277 / 286 |
| uterus | 100% | 906.91 | 170 / 170 | 86% | 15.70 | 394 / 459 |
| ovary | 100% | 940.12 | 180 / 180 | 55% | 7.71 | 238 / 430 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 32.31 | 29 / 29 |
| spleen | 100% | 728.01 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 15.63 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 16.86 | 1 / 1 |
| adipose | 100% | 871.28 | 1202 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 833.41 | 1330 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 99% | 689.73 | 794 / 803 | 0% | 0 | 0 / 0 |
| heart | 98% | 1226.18 | 846 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 93% | 13.75 | 74 / 80 |
| peripheral blood | 67% | 530.94 | 626 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0098734 | Biological process | macromolecule depalmitoylation |
| GO_0160049 | Biological process | negative regulation of cGAS/STING signaling pathway |
| GO_0008150 | Biological process | biological_process |
| GO_0002084 | Biological process | protein depalmitoylation |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0016298 | Molecular function | lipase activity |
| GO_0004622 | Molecular function | lysophospholipase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0052689 | Molecular function | carboxylic ester hydrolase activity |
| GO_0016788 | Molecular function | hydrolase activity, acting on ester bonds |
| GO_0008474 | Molecular function | palmitoyl-(protein) hydrolase activity |
| Gene name | LYPLAL1 |
| Protein name | palmitoyl-protein hydrolase (EC 3.1.2.22) Lysophospholipase-like protein 1 (EC 3.1.2.22) |
| Synonyms | hCG_24907 |
| Description | FUNCTION: Palmitoyl thioesterase that catalyzes depalmitoylation of CGAS and KCNMA1 . Acts as a regulator of innate immunity by mediating depalmitoylation of CGAS, thereby preventing CGAS homodimerization and cyclic GMP-AMP synthase activity . Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site . . |
| Accessions | Q5VWZ2 B3KVW3 ENST00000366928.10 [Q5VWZ2-1] ENST00000366927.3 [Q5VWZ2-2] |