LYPLAL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0098734Biological processmacromolecule depalmitoylation
GO_0160049Biological processnegative regulation of cGAS/STING signaling pathway
GO_0008150Biological processbiological_process
GO_0002084Biological processprotein depalmitoylation
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0016298Molecular functionlipase activity
GO_0004622Molecular functionlysophospholipase activity
GO_0005515Molecular functionprotein binding
GO_0052689Molecular functioncarboxylic ester hydrolase activity
GO_0016788Molecular functionhydrolase activity, acting on ester bonds
GO_0008474Molecular functionpalmitoyl-(protein) hydrolase activity

IV. Literature review

[source]
Gene nameLYPLAL1
Protein namepalmitoyl-protein hydrolase (EC 3.1.2.22)
Lysophospholipase-like protein 1 (EC 3.1.2.22)
SynonymshCG_24907
DescriptionFUNCTION: Palmitoyl thioesterase that catalyzes depalmitoylation of CGAS and KCNMA1 . Acts as a regulator of innate immunity by mediating depalmitoylation of CGAS, thereby preventing CGAS homodimerization and cyclic GMP-AMP synthase activity . Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site . .

AccessionsQ5VWZ2
B3KVW3
ENST00000366928.10 [Q5VWZ2-1]
ENST00000366927.3 [Q5VWZ2-2]