LSM8 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of LSM8 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LSM8 at tissue level.

III. Associated gene sets

GO_0000398Biological processmRNA splicing, via spliceosome
GO_0046540Cellular componentU4/U6 x U5 tri-snRNP complex
GO_0071011Cellular componentprecatalytic spliceosome
GO_0120115Cellular componentLsm2-8 complex
GO_0005654Cellular componentnucleoplasm
GO_0005688Cellular componentU6 snRNP
GO_0071005Cellular componentU2-type precatalytic spliceosome
GO_0005634Cellular componentnucleus
GO_0017070Molecular functionU6 snRNA binding
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameLSM8
Protein nameU6 snRNA-associated Sm-like protein LSm8
SynonymshCG_14869
tcag7.58
DescriptionFUNCTION: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) . The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA . .

FUNCTION: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. .

FUNCTION: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. .

FUNCTION: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. .

FUNCTION: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. .

AccessionsENST00000422760.1
ENST00000424702.1
O95777
F2Z2Y6
C9JIZ0
A4D0W0
ENST00000249299.7
ENST00000411938.1
C9JNV3