LRWD1 | OmnibusX

Name	Number of supported studies	Average coverage
ciliated cell	11 studies	34% ± 14%	Explore
deuterosomal cell	3 studies	18% ± 1%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of LRWD1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	972.51	180 / 180	100%	13.72	430 / 430
esophagus	100%	787.98	1443 / 1445	100%	12.12	183 / 183
brain	100%	1382.40	2631 / 2642	100%	23.64	705 / 705
uterus	100%	1108.81	170 / 170	100%	15.16	457 / 459
thymus	100%	1181.41	653 / 653	100%	12.87	602 / 605
skin	100%	801.03	1804 / 1809	99%	23.19	468 / 472
breast	100%	872.84	459 / 459	99%	11.97	1104 / 1118
adrenal gland	100%	1678.67	258 / 258	99%	13.59	227 / 230
intestine	100%	1096.15	966 / 966	99%	13.47	520 / 527
prostate	100%	988.39	245 / 245	99%	9.72	495 / 502
bladder	100%	945.67	21 / 21	98%	14.59	496 / 504
liver	100%	792.10	226 / 226	98%	9.46	398 / 406
lung	100%	1116.15	576 / 578	98%	13.14	1136 / 1155
stomach	100%	744.41	358 / 359	98%	12.54	281 / 286
kidney	100%	994.74	89 / 89	97%	9.43	877 / 901
pancreas	97%	524.51	319 / 328	99%	10.81	176 / 178
lymph node	0%	0	0 / 0	100%	23.32	29 / 29
spleen	100%	2499.17	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	13.89	45 / 45
ureter	0%	0	0 / 0	100%	15.76	1 / 1
blood vessel	100%	784.31	1332 / 1335	0%	0	0 / 0
adipose	100%	827.81	1201 / 1204	0%	0	0 / 0
peripheral blood	99%	1935.77	921 / 929	0%	0	0 / 0
muscle	99%	789.55	796 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	99%	10.63	79 / 80
heart	95%	598.29	820 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0006325	Biological process	chromatin organization
GO_0071169	Biological process	establishment of protein localization to chromatin
GO_0006270	Biological process	DNA replication initiation
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005664	Cellular component	nuclear origin of replication recognition complex
GO_0005730	Cellular component	nucleolus
GO_0005813	Cellular component	centrosome
GO_0000776	Cellular component	kinetochore
GO_0000781	Cellular component	chromosome, telomeric region
GO_0005654	Cellular component	nucleoplasm
GO_0005721	Cellular component	pericentric heterochromatin
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0035064	Molecular function	methylated histone binding
GO_0008327	Molecular function	methyl-CpG binding
GO_0005515	Molecular function	protein binding
GO_0003682	Molecular function	chromatin binding

Gene name	LRWD1
Protein name	Leucine rich repeats and WD repeat domain containing 1 Leucine-rich repeat and WD repeat-containing protein 1 (Centromere protein 33) (CENP-33) (Origin recognition complex-associated protein) (ORC-associated protein) (ORCA)
Synonyms	ORCA CENP-33
Description	FUNCTION: Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability. .
Accessions	H7C5S6 ENST00000626402.1 ENST00000464107.5 F8WBP5 ENST00000463739.5 F8WDB4 ENST00000476270.1 ENST00000292616.10 H7C5N7 H7C4Q9 ENST00000468175.1 Q9UFC0 ENST00000485808.5

LRWD1 report