LRRTM2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002091Biological processnegative regulation of receptor internalization
GO_0050808Biological processsynapse organization
GO_0051965Biological processpositive regulation of synapse assembly
GO_0060291Biological processlong-term synaptic potentiation
GO_0099151Biological processregulation of postsynaptic density assembly
GO_0099634Cellular componentpostsynaptic specialization membrane
GO_0005615Cellular componentextracellular space
GO_0098978Cellular componentglutamatergic synapse
GO_0060076Cellular componentexcitatory synapse
GO_0098839Cellular componentpostsynaptic density membrane
GO_0098982Cellular componentGABA-ergic synapse
GO_0098685Cellular componentSchaffer collateral - CA1 synapse
GO_0098686Cellular componenthippocampal mossy fiber to CA3 synapse
GO_0042043Molecular functionneurexin family protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLRRTM2
Protein nameLeucine rich repeat transmembrane neuronal 2
Leucine-rich repeat transmembrane neuronal protein 2 (Leucine-rich repeat neuronal 2 protein)
SynonymsKIAA0416
LRRN2
DescriptionFUNCTION: Involved in the development and maintenance of excitatory synapses in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity). .

AccessionsE5RHE5
E5RIQ2
ENST00000518785.1
ENST00000521094.2
O43300
ENST00000274711.7