LMNB2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LMNB2 at tissue level.

III. Associated gene sets

GO_0051664Biological processnuclear pore localization
GO_0031507Biological processheterochromatin formation
GO_0007010Biological processcytoskeleton organization
GO_0006998Biological processnuclear envelope organization
GO_0008150Biological processbiological_process
GO_0090435Biological processprotein localization to nuclear envelope
GO_0007097Biological processnuclear migration
GO_0005652Cellular componentnuclear lamina
GO_0031965Cellular componentnuclear membrane
GO_0005635Cellular componentnuclear envelope
GO_0005882Cellular componentintermediate filament
GO_0005200Molecular functionstructural constituent of cytoskeleton
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameLMNB2
Protein nameLamin-B2
Lamin B2, isoform CRA_b (Lamin B3)
SynonymsLMN2
hCG_2004338
DescriptionFUNCTION: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane . Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics . The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively . .

AccessionsA0A0A7M1X5
ENST00000325327.4
Q03252