LIN28A report

I. Expression across cell types

Insufficient scRNA-seq data for expression of LIN28A at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LIN28A at tissue level.

III. Associated gene sets

GO_2000632Biological processnegative regulation of pre-miRNA processing
GO_0071333Biological processcellular response to glucose stimulus
GO_2000767Biological processpositive regulation of cytoplasmic translation
GO_0071076Biological processRNA 3' uridylation
GO_1901724Biological processpositive regulation of cell proliferation involved in kidney development
GO_0010587Biological processmiRNA catabolic process
GO_0045686Biological processnegative regulation of glial cell differentiation
GO_0031054Biological processpre-miRNA processing
GO_0007281Biological processgerm cell development
GO_0019827Biological processstem cell population maintenance
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0048863Biological processstem cell differentiation
GO_0045666Biological processpositive regulation of neuron differentiation
GO_0032008Biological processpositive regulation of TOR signaling
GO_0031123Biological processRNA 3'-end processing
GO_0017148Biological processnegative regulation of translation
GO_0005730Cellular componentnucleolus
GO_0000932Cellular componentP-body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005791Cellular componentrough endoplasmic reticulum
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_1990825Molecular functionsequence-specific mRNA binding
GO_0031369Molecular functiontranslation initiation factor binding
GO_0070883Molecular functionpre-miRNA binding
GO_0003729Molecular functionmRNA binding
GO_0140517Molecular functionprotein-RNA adaptor activity
GO_0008270Molecular functionzinc ion binding
GO_0003723Molecular functionRNA binding
GO_0002151Molecular functionG-quadruplex RNA binding
GO_0035198Molecular functionmiRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLIN28A
Protein nameProtein lin-28 homolog A (Lin-28A) (Zinc finger CCHC domain-containing protein 1)
SynonymsZCCHC1
LIN28
CSDD1
DescriptionFUNCTION: RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism . Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (Probable). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds the miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits TUT4 and TUT7 uridylyltransferases . This results in the terminal uridylation of target pre-miRNAs . Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells . Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins. Binds to and enhances the translation of mRNAs for several metabolic enzymes, such as PFKP, PDHA1 or SDHA, increasing glycolysis and oxidative phosphorylation. Which, with the let-7 repression may enhance tissue repair in adult tissue (By similarity). .

AccessionsENST00000326279.11
Q9H9Z2
ENST00000254231.4