LIG3 | OmnibusX

Name	Number of supported studies	Average coverage
glutamatergic neuron	4 studies	18% ± 2%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of LIG3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1553.56	1445 / 1445	100%	10.61	183 / 183
prostate	100%	2210.73	245 / 245	100%	17.89	502 / 502
stomach	100%	1201.52	359 / 359	100%	9.04	286 / 286
breast	100%	1465.69	459 / 459	100%	15.04	1117 / 1118
intestine	100%	1509.62	966 / 966	100%	8.93	526 / 527
lung	100%	1275.02	577 / 578	100%	10.36	1153 / 1155
skin	100%	1819.21	1809 / 1809	100%	11.18	470 / 472
bladder	100%	1770.14	21 / 21	99%	9.61	501 / 504
ovary	100%	1971.74	180 / 180	99%	7.24	426 / 430
pancreas	100%	1100.04	328 / 328	99%	6.18	176 / 178
uterus	100%	2507.28	170 / 170	99%	8.40	453 / 459
thymus	100%	1797.07	653 / 653	99%	7.67	596 / 605
brain	98%	939.73	2583 / 2642	100%	7.74	704 / 705
kidney	100%	919.21	89 / 89	93%	4.80	835 / 901
liver	100%	781.46	226 / 226	92%	4.57	372 / 406
adrenal gland	100%	1352.29	258 / 258	86%	4.14	198 / 230
blood vessel	100%	1253.31	1335 / 1335	0%	0	0 / 0
muscle	100%	1277.48	803 / 803	0%	0	0 / 0
spleen	100%	1776.52	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	6.96	45 / 45
ureter	0%	0	0 / 0	100%	4.17	1 / 1
adipose	100%	1029.88	1203 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	6.09	28 / 29
heart	96%	876.32	828 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	91%	8.00	73 / 80
peripheral blood	89%	997.80	825 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0006288	Biological process	base-excision repair, DNA ligation
GO_0006287	Biological process	base-excision repair, gap-filling
GO_0006273	Biological process	lagging strand elongation
GO_0006302	Biological process	double-strand break repair
GO_0033151	Biological process	V(D)J recombination
GO_0051301	Biological process	cell division
GO_0000724	Biological process	double-strand break repair via homologous recombination
GO_0071897	Biological process	DNA biosynthetic process
GO_0090298	Biological process	negative regulation of mitochondrial DNA replication
GO_0070421	Cellular component	DNA ligase III-XRCC1 complex
GO_0005739	Cellular component	mitochondrion
GO_0005654	Cellular component	nucleoplasm
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0008270	Molecular function	zinc ion binding
GO_0005524	Molecular function	ATP binding
GO_0003910	Molecular function	DNA ligase (ATP) activity
GO_0003909	Molecular function	DNA ligase activity
GO_0005515	Molecular function	protein binding

Gene name	LIG3
Protein name	Ligase III, DNA, ATP-dependent DNA ligase 3 DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3)
Synonyms
Description	FUNCTION: Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair . .
Accessions	C4B7Q3 K7EJR4 ENST00000378526.9 [P49916-1] ENST00000585370.1 K7ELY6 ENST00000585941.5 ENST00000588109.5 K7ENR9 ENST00000262327.9 [P49916-2] K7EQB6 ENST00000592690.1 P49916 K7ERZ5 ENST00000585740.5

LIG3 report