LGALS8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1904977Biological processlymphatic endothelial cell migration
GO_0098586Biological processcellular response to virus
GO_0098792Biological processxenophagy
GO_0005615Cellular componentextracellular space
GO_0005829Cellular componentcytosol
GO_0031410Cellular componentcytoplasmic vesicle
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0030246Molecular functioncarbohydrate binding
GO_0005515Molecular functionprotein binding
GO_0005178Molecular functionintegrin binding

IV. Literature review

[source]
Gene nameLGALS8
Protein nameGalectin
Galectin-8g
Alternative protein LGALS8
Galectin 8
Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1)
Synonyms
DescriptionFUNCTION: Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy . Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture . Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 . Required to restrict infection of bacterial invasion such as S.typhimurium . Also required to restrict infection of Picornaviridae viruses . Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans . .

AccessionsENST00000526634.5 [O00214-1]
E9PJ77
B3F166
ENST00000416919.6
Q96QS7
ENST00000481485.5
ENST00000526589.5 [O00214-2]
ENST00000442397.6
E9PRN3
ENST00000525042.1
ENST00000434231.6
O00214
ENST00000238181.11
ENST00000430527.6
ENST00000450372.6 [O00214-2]
L8E9E9
E9PPL1
ENST00000529489.5
ENST00000323938.10
F6V2D4
Q5T3P9
ENST00000352231.6 [O00214-2]
H7BXD8
ENST00000454943.6
B1ANM0
E9PNC2
E9PPM4
ENST00000527974.5 [O00214-2]
ENST00000341872.10 [O00214-1]
E9PN19
ENST00000406509.7
ENST00000366584.9 [O00214-1]