LEO1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001711Biological processendodermal cell fate commitment
GO_0031124Biological processmRNA 3'-end processing
GO_0045638Biological processnegative regulation of myeloid cell differentiation
GO_0006368Biological processtranscription elongation by RNA polymerase II
GO_0016055Biological processWnt signaling pathway
GO_0019827Biological processstem cell population maintenance
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005813Cellular componentcentrosome
GO_0016593Cellular componentCdc73/Paf1 complex
GO_0005654Cellular componentnucleoplasm
GO_0001650Cellular componentfibrillar center
GO_0005634Cellular componentnucleus
GO_1990269Molecular functionRNA polymerase II C-terminal domain phosphoserine binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLEO1
Protein nameRNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein)
SynonymsRDL
DescriptionFUNCTION: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling. .

AccessionsQ8WVC0
ENST00000299601.10 [Q8WVC0-1]
ENST00000315141.5 [Q8WVC0-2]