LEMD3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030514Biological processnegative regulation of BMP signaling pathway
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0032926Biological processnegative regulation of activin receptor signaling pathway
GO_0031965Cellular componentnuclear membrane
GO_0005637Cellular componentnuclear inner membrane
GO_0016020Cellular componentmembrane
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding
GO_1990446Molecular functionU1 snRNP binding

IV. Literature review

[source]
Gene nameLEMD3
Protein nameInner nuclear membrane protein Man1 (LEM domain-containing protein 3)
SynonymsMAN1
DescriptionFUNCTION: Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. .

AccessionsENST00000308330.3
Q9Y2U8