LEMD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071168Biological processprotein localization to chromatin
GO_0060914Biological processheart formation
GO_0035914Biological processskeletal muscle cell differentiation
GO_0022008Biological processneurogenesis
GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0006998Biological processnuclear envelope organization
GO_0071763Biological processnuclear membrane organization
GO_0043409Biological processnegative regulation of MAPK cascade
GO_0005783Cellular componentendoplasmic reticulum
GO_0005637Cellular componentnuclear inner membrane
GO_0000785Cellular componentchromatin
GO_0031965Cellular componentnuclear membrane
GO_0034399Cellular componentnuclear periphery
GO_0005819Cellular componentspindle
GO_0005635Cellular componentnuclear envelope
GO_0016020Cellular componentmembrane
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLEMD2
Protein nameLEMD2
LEM domain nuclear envelope protein 2
LEM domain-containing protein 2 (hLEM2)
Synonyms
DescriptionFUNCTION: Nuclear lamina-associated inner nuclear membrane protein that is involved in nuclear structure organization, maintenance of nuclear envelope (NE) integrity and NE reformation after mitosis . Plays a role as transmembrane adapter for the endosomal sorting complexes required for transport (ESCRT), and is thereby involved in ESCRT-mediated NE reformation . Promotes ESCRT-mediated NE closure by recruiting CHMP7 and downstream ESCRT-III proteins IST1/CHMP8 and CHMP2A to the reforming NE during anaphase . During nuclear reassembly, condenses into a liquid-like coating around microtubule spindles and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin, and the spindle to facilitate early nuclear sealing . Plays a role in the organization of heterochromatin associated with the NE and in the maintenance of NE organization under mechanical stress (By similarity). Required for embryonic development and involved in regulation of several signaling pathways such as MAPK and AKT (By similarity). Required for myoblast differentiation involving regulation of ERK signaling (By similarity). Essential for cardiac homeostasis and proper heart function (By similarity). .

AccessionsD6R958
ENST00000508327.5 [Q8NC56-2]
A0A220T1R7
H7C2Z0
ENST00000421671.6
ENST00000442696.6
ENST00000504692.1
H0Y9B7
D6RBV0
ENST00000293760.10 [Q8NC56-1]
Q8NC56
ENST00000506578.5
H0Y8H8
ENST00000513701.1