LAMP3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LAMP3 at tissue level.

III. Associated gene sets

GO_0043154Biological processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0010628Biological processpositive regulation of gene expression
GO_0035455Biological processresponse to interferon-alpha
GO_1901799Biological processnegative regulation of proteasomal protein catabolic process
GO_0002250Biological processadaptive immune response
GO_0046718Biological processsymbiont entry into host cell
GO_0010506Biological processregulation of autophagy
GO_1903900Biological processregulation of viral life cycle
GO_0072594Biological processestablishment of protein localization to organelle
GO_0031902Cellular componentlate endosome membrane
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005769Cellular componentearly endosome
GO_0031901Cellular componentearly endosome membrane
GO_0009986Cellular componentcell surface
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0097233Cellular componentalveolar lamellar body membrane
GO_0031982Cellular componentvesicle
GO_0005765Cellular componentlysosomal membrane

IV. Literature review

[source]
Gene nameLAMP3
Protein nameLysosomal associated membrane protein 3
Lysosome-associated membrane glycoprotein 3 (LAMP-3) (Lysosomal-associated membrane protein 3) (DC-lysosome-associated membrane glycoprotein) (DC LAMP) (Protein TSC403) (CD antigen CD208)
SynonymsTSC403
DCLAMP
DescriptionFUNCTION: Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction . Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process . Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway . May also play a role in dendritic cell function and in adaptive immunity . .; FUNCTION: (Microbial infection) Plays a positive role in post-entry steps of influenza A virus replication, either virus uncoating, cytosolic transport, or nuclear import of viral components, and promotes nuclear accumulation of influenza nucleoprotein/NP at early stages of viral infection. .; FUNCTION: (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F. .; FUNCTION: (Microbial infection) Promotes the intracellular proliferation of Salmonella typhimuium. .

AccessionsQ9UQV4
ENST00000470251.1
ENST00000466939.1
ENST00000476015.1
C9JYP5
ENST00000265598.8
C9JDI8
E7ETP9