I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 10 studies | 31% ± 15% | |
| squamous epithelial cell | 3 studies | 27% ± 7% | |
| podocyte | 3 studies | 35% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 10 studies | 31% ± 15% | |
| squamous epithelial cell | 3 studies | 27% ± 7% | |
| podocyte | 3 studies | 35% ± 6% |
Insufficient scRNA-seq data for expression of KLK6 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 94% | 2403.47 | 2473 / 2642 | 62% | 26.91 | 435 / 705 |
| ovary | 9% | 28.58 | 16 / 180 | 96% | 224.39 | 412 / 430 |
| esophagus | 37% | 1679.60 | 541 / 1445 | 66% | 68.41 | 121 / 183 |
| kidney | 89% | 829.46 | 79 / 89 | 2% | 1.94 | 15 / 901 |
| spleen | 74% | 262.56 | 178 / 241 | 0% | 0 | 0 / 0 |
| pancreas | 0% | 0 | 0 / 328 | 64% | 56.88 | 114 / 178 |
| breast | 45% | 259.49 | 207 / 459 | 16% | 15.61 | 176 / 1118 |
| intestine | 0% | 0 | 0 / 966 | 46% | 39.75 | 243 / 527 |
| skin | 31% | 241.65 | 558 / 1809 | 14% | 10.64 | 65 / 472 |
| stomach | 1% | 2.70 | 2 / 359 | 41% | 40.95 | 118 / 286 |
| uterus | 11% | 152.56 | 19 / 170 | 26% | 14.96 | 120 / 459 |
| tonsil | 0% | 0 | 0 / 0 | 27% | 9.46 | 12 / 45 |
| bladder | 0% | 0 | 0 / 21 | 25% | 22.35 | 125 / 504 |
| lung | 0% | 0 | 0 / 578 | 20% | 13.00 | 236 / 1155 |
| thymus | 0% | 0 | 0 / 653 | 14% | 3.32 | 82 / 605 |
| liver | 0% | 0 | 0 / 226 | 1% | 0.47 | 4 / 406 |
| adipose | 0% | 0.90 | 5 / 1204 | 0% | 0 | 0 / 0 |
| prostate | 0% | 0.72 | 1 / 245 | 0% | 0 | 0 / 502 |
| muscle | 0% | 0.42 | 2 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 0.95 | 3 / 1335 | 0% | 0 | 0 / 0 |
| heart | 0% | 0.50 | 1 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0.23 | 1 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| adrenal gland | 0% | 0 | 0 / 258 | 0% | 0 | 0 / 230 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0042552 | Biological process | myelination |
| GO_0016540 | Biological process | protein autoprocessing |
| GO_0042246 | Biological process | tissue regeneration |
| GO_0030574 | Biological process | collagen catabolic process |
| GO_0045745 | Biological process | positive regulation of G protein-coupled receptor signaling pathway |
| GO_0045595 | Biological process | regulation of cell differentiation |
| GO_0007417 | Biological process | central nervous system development |
| GO_0010975 | Biological process | regulation of neuron projection development |
| GO_0042982 | Biological process | amyloid precursor protein metabolic process |
| GO_0009611 | Biological process | response to wounding |
| GO_0042445 | Biological process | hormone metabolic process |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0045171 | Cellular component | intercellular bridge |
| GO_0001533 | Cellular component | cornified envelope |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0030141 | Cellular component | secretory granule |
| GO_0031965 | Cellular component | nuclear membrane |
| GO_0005515 | Molecular function | protein binding |
| GO_0004252 | Molecular function | serine-type endopeptidase activity |
| Gene name | KLK6 |
| Protein name | Kallikrein related peptidase 6 Kallikrein-related peptidase 6 transcript variant 10 Kallikrein-related peptidase 6 transcript variant 11 Kallikrein 6 variant 4 Kallikrein-related peptidase 6 transcript variant 9 Kallikrein-related peptidase 6 transcript variant 6 Kallikrein-6 (EC 3.4.21.-) (Neurosin) (Protease M) (SP59) (Serine protease 18) (Serine protease 9) (Zyme) Kallikrein-related peptidase 6 transcript variant 8 Kallikrein-related peptidase 6 transcript variant 7 |
| Synonyms | PRSS9 Bssp SP59 Klk7 hK6 PRSS18 |
| Description | FUNCTION: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. . |
| Accessions | ENST00000391808.5 [Q92876-2] A0A2I2MP52 ENST00000599881.5 [Q92876-3] A0A2I2MP54 A0A2I2MP53 ENST00000310157.7 [Q92876-1] ENST00000599690.1 Q6JIA6 A0A2I2MP50 M0QYA5 A0A2I2MP55 A0A2I2MP51 ENST00000376851.7 [Q92876-1] ENST00000597379.5 [Q92876-3] ENST00000594641.1 [Q92876-1] Q92876 |
