Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 16 studies | 23% ± 8% | |
oligodendrocyte | 12 studies | 32% ± 8% | |
glutamatergic neuron | 10 studies | 44% ± 24% | |
microglial cell | 8 studies | 24% ± 7% | |
endothelial cell of lymphatic vessel | 6 studies | 34% ± 20% | |
macrophage | 6 studies | 32% ± 10% | |
type II pneumocyte | 6 studies | 23% ± 8% | |
astrocyte | 5 studies | 32% ± 11% | |
monocyte | 5 studies | 30% ± 12% | |
neuron | 4 studies | 29% ± 12% | |
myeloid cell | 4 studies | 22% ± 4% | |
dendritic cell | 4 studies | 22% ± 2% | |
GABAergic neuron | 4 studies | 38% ± 10% | |
classical monocyte | 3 studies | 20% ± 2% | |
epithelial cell | 3 studies | 34% ± 16% | |
vein endothelial cell | 3 studies | 34% ± 20% | |
hepatocyte | 3 studies | 46% ± 29% | |
oligodendrocyte precursor cell | 3 studies | 22% ± 1% | |
alveolar macrophage | 3 studies | 30% ± 11% | |
interneuron | 3 studies | 34% ± 11% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 14 studies | 31% ± 18% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 5188.23 | 2642 / 2642 | 100% | 33.33 | 705 / 705 |
esophagus | 100% | 1980.46 | 1444 / 1445 | 99% | 17.77 | 182 / 183 |
lung | 99% | 2491.92 | 575 / 578 | 100% | 21.31 | 1152 / 1155 |
thymus | 100% | 1651.40 | 652 / 653 | 99% | 39.31 | 598 / 605 |
kidney | 100% | 1550.35 | 89 / 89 | 98% | 14.97 | 880 / 901 |
intestine | 99% | 1104.22 | 959 / 966 | 98% | 12.85 | 515 / 527 |
breast | 100% | 1995.12 | 459 / 459 | 97% | 17.60 | 1083 / 1118 |
uterus | 98% | 1206.40 | 167 / 170 | 98% | 22.22 | 448 / 459 |
bladder | 100% | 1245.43 | 21 / 21 | 96% | 14.87 | 483 / 504 |
prostate | 99% | 1289.21 | 243 / 245 | 97% | 12.65 | 485 / 502 |
adrenal gland | 100% | 1881.38 | 257 / 258 | 95% | 14.95 | 219 / 230 |
stomach | 97% | 1107.75 | 348 / 359 | 97% | 11.49 | 277 / 286 |
liver | 100% | 1680.79 | 226 / 226 | 93% | 13.00 | 378 / 406 |
skin | 98% | 1123.97 | 1774 / 1809 | 92% | 13.00 | 432 / 472 |
ovary | 80% | 617.11 | 144 / 180 | 95% | 11.23 | 409 / 430 |
pancreas | 74% | 564.12 | 242 / 328 | 98% | 20.66 | 175 / 178 |
spleen | 100% | 2861.89 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 10.83 | 1 / 1 |
adipose | 100% | 1759.35 | 1203 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1817.96 | 1331 / 1335 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 19.41 | 44 / 45 |
lymph node | 0% | 0 | 0 / 0 | 97% | 14.74 | 28 / 29 |
peripheral blood | 86% | 2913.74 | 800 / 929 | 0% | 0 | 0 / 0 |
heart | 74% | 576.42 | 634 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 51% | 3.97 | 41 / 80 |
muscle | 41% | 293.20 | 332 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0016567 | Biological process | protein ubiquitination |
GO_0001726 | Cellular component | ruffle |
GO_0015629 | Cellular component | actin cytoskeleton |
GO_0005829 | Cellular component | cytosol |
GO_0030027 | Cellular component | lamellipodium |
GO_0031463 | Cellular component | Cul3-RING ubiquitin ligase complex |
GO_0005737 | Cellular component | cytoplasm |
GO_1990756 | Molecular function | ubiquitin-like ligase-substrate adaptor activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0005515 | Molecular function | protein binding |
GO_0003779 | Molecular function | actin binding |
Gene name | KLHL2 |
Protein name | Kelch like family member 2 Kelch-like protein 2 (Actin-binding protein Mayven) Kelch like family member 2 (cDNA FLJ60241, highly similar to Kelch-like protein 2) |
Synonyms | |
Description | FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, WNK1, WNK3 and WNK4, leading most often to their proteasomal degradation . The BCR(KLHL2) complex catalyzes ubiquitination and degradation of NPTXR (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4 . Plays a role in the reorganization of the actin cytoskeleton . Promotes growth of cell projections in oligodendrocyte precursors . . |
Accessions | ENST00000538127.5 [O95198-3] ENST00000506761.1 E9PEX9 ENST00000511305.5 D6RAP5 ENST00000509704.5 O95198 B4DFZ5 ENST00000506824.5 D6RGC3 ENST00000421009.6 D6R9G5 ENST00000226725.11 [O95198-1] ENST00000514860.5 [O95198-2] |