KLHL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0001726Cellular componentruffle
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0030027Cellular componentlamellipodium
GO_0031463Cellular componentCul3-RING ubiquitin ligase complex
GO_0005737Cellular componentcytoplasm
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameKLHL2
Protein nameKelch like family member 2
Kelch-like protein 2 (Actin-binding protein Mayven)
Kelch like family member 2 (cDNA FLJ60241, highly similar to Kelch-like protein 2)
Synonyms
DescriptionFUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, WNK1, WNK3 and WNK4, leading most often to their proteasomal degradation . The BCR(KLHL2) complex catalyzes ubiquitination and degradation of NPTXR (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4 . Plays a role in the reorganization of the actin cytoskeleton . Promotes growth of cell projections in oligodendrocyte precursors . .

AccessionsENST00000538127.5 [O95198-3]
ENST00000506761.1
E9PEX9
ENST00000511305.5
D6RAP5
ENST00000509704.5
O95198
B4DFZ5
ENST00000506824.5
D6RGC3
ENST00000421009.6
D6R9G5
ENST00000226725.11 [O95198-1]
ENST00000514860.5 [O95198-2]