KLF15 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KLF15 at tissue level.

III. Associated gene sets

GO_1901653Biological processcellular response to peptide
GO_0046326Biological processpositive regulation of glucose import
GO_0072112Biological processpodocyte differentiation
GO_0014898Biological processcardiac muscle hypertrophy in response to stress
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0010001Biological processglial cell differentiation
GO_0032868Biological processresponse to insulin
GO_0001678Biological processintracellular glucose homeostasis
GO_2000757Biological processnegative regulation of peptidyl-lysine acetylation
GO_0030111Biological processregulation of Wnt signaling pathway
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKLF15
Protein nameKrueppel-like factor 15 (Kidney-enriched krueppel-like factor)
SynonymsKKLF
DescriptionFUNCTION: Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation. .

AccessionsQ9UIH9
ENST00000296233.4