KHDRBS3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006397Biological processmRNA processing
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0017124Molecular functionSH3 domain binding
GO_0019904Molecular functionprotein domain specific binding
GO_0005515Molecular functionprotein binding
GO_0042802Molecular functionidentical protein binding
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameKHDRBS3
Protein nameKH RNA binding domain containing, signal transduction associated 3
Alternative protein KHDRBS3
KH domain-containing, RNA-binding, signal transduction-associated protein 3 (RNA-binding protein T-Star) (Sam68-like mammalian protein 2) (SLM-2) (Sam68-like phosphotyrosine protein)
SynonymsSALP
SLM2
DescriptionFUNCTION: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 . Involved in splice site selection of vascular endothelial growth factor . In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members . Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity (By similarity). May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing (By similarity). Can bind FABP9 mRNA (By similarity). May play a role as a negative regulator of cell growth. Inhibits cell proliferation. .; FUNCTION: (Microbial infection) Involved in post-transcriptional regulation of HIV-1 gene expression. .

AccessionsENST00000522578.2
E5RJZ9
A0A994J7I5
H0YAQ1
L8EC47
ENST00000517394.5
H0YB45
ENST00000355849.10 [O75525-1]
ENST00000524199.5
A0A994J4I6
ENST00000517859.5
ENST00000521461.5
ENST00000524282.1
O75525
H0YAQ3
E5RG12
ENST00000704572.1
ENST00000520981.5
L8EAJ0
E5RHD3