KHDRBS2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006397Biological processmRNA processing
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0008143Molecular functionpoly(A) binding
GO_0042169Molecular functionSH2 domain binding
GO_0008266Molecular functionpoly(U) RNA binding
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameKHDRBS2
Protein nameAlternative protein KHDRBS2
KH domain-containing, RNA-binding, signal transduction-associated protein 2
KH domain-containing, RNA-binding, signal transduction-associated protein 2 (Sam68-like mammalian protein 1) (SLM-1) (hSLM-1)
SynonymsSLM1
DescriptionFUNCTION: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis. .

AccessionsENST00000281156.5
A0A6Q8PGH5
L8ECN3
Q5VWX1
ENST00000675091.1