Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 15 studies | 29% ± 12% | |
microglial cell | 10 studies | 28% ± 9% | |
macrophage | 9 studies | 36% ± 12% | |
myeloid cell | 7 studies | 22% ± 5% | |
fibroblast | 7 studies | 20% ± 5% | |
classical monocyte | 6 studies | 27% ± 7% | |
dendritic cell | 6 studies | 26% ± 7% | |
ciliated cell | 6 studies | 21% ± 6% | |
glutamatergic neuron | 5 studies | 36% ± 16% | |
epithelial cell | 5 studies | 36% ± 20% | |
club cell | 5 studies | 22% ± 6% | |
monocyte | 5 studies | 28% ± 10% | |
goblet cell | 5 studies | 34% ± 19% | |
respiratory goblet cell | 4 studies | 34% ± 13% | |
GABAergic neuron | 4 studies | 34% ± 9% | |
astrocyte | 4 studies | 29% ± 8% | |
endothelial cell of lymphatic vessel | 4 studies | 22% ± 4% | |
B cell | 3 studies | 23% ± 5% | |
oligodendrocyte precursor cell | 3 studies | 25% ± 10% | |
enteroendocrine cell | 3 studies | 22% ± 5% | |
type I pneumocyte | 3 studies | 19% ± 4% | |
type II pneumocyte | 3 studies | 20% ± 4% | |
basal cell | 3 studies | 30% ± 12% | |
interneuron | 3 studies | 32% ± 12% | |
neuron | 3 studies | 35% ± 12% | |
mucus secreting cell | 3 studies | 28% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3000.01 | 1444 / 1445 | 100% | 20.91 | 183 / 183 |
stomach | 100% | 2695.84 | 359 / 359 | 100% | 20.88 | 285 / 286 |
lung | 100% | 3574.20 | 577 / 578 | 100% | 15.47 | 1151 / 1155 |
intestine | 100% | 3619.94 | 965 / 966 | 99% | 22.26 | 523 / 527 |
breast | 100% | 4589.77 | 459 / 459 | 98% | 16.11 | 1096 / 1118 |
prostate | 100% | 1910.33 | 244 / 245 | 98% | 13.51 | 493 / 502 |
pancreas | 97% | 1438.70 | 318 / 328 | 97% | 11.95 | 173 / 178 |
uterus | 100% | 2766.76 | 170 / 170 | 93% | 11.49 | 428 / 459 |
thymus | 100% | 2272.29 | 650 / 653 | 92% | 7.12 | 554 / 605 |
bladder | 100% | 2413.90 | 21 / 21 | 91% | 12.60 | 458 / 504 |
ovary | 99% | 1593.32 | 179 / 180 | 87% | 6.26 | 374 / 430 |
skin | 98% | 4961.66 | 1781 / 1809 | 85% | 9.01 | 403 / 472 |
kidney | 85% | 1210.54 | 76 / 89 | 91% | 9.37 | 819 / 901 |
brain | 78% | 1025.44 | 2070 / 2642 | 97% | 11.38 | 683 / 705 |
liver | 98% | 1444.42 | 222 / 226 | 69% | 4.21 | 279 / 406 |
adrenal gland | 79% | 758.26 | 203 / 258 | 62% | 3.52 | 143 / 230 |
adipose | 100% | 4840.64 | 1204 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 6134.25 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2632.50 | 241 / 241 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2822.21 | 1333 / 1335 | 0% | 0 | 0 / 0 |
heart | 96% | 1858.29 | 826 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 12.84 | 43 / 45 |
peripheral blood | 84% | 2742.78 | 782 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 76% | 8.45 | 22 / 29 |
eye | 0% | 0 | 0 / 0 | 46% | 2.90 | 37 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0006482 | Biological process | protein demethylation |
GO_0006338 | Biological process | chromatin remodeling |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0030901 | Biological process | midbrain development |
GO_0005730 | Cellular component | nucleolus |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0035064 | Molecular function | methylated histone binding |
GO_0032454 | Molecular function | histone H3K9 demethylase activity |
GO_0016706 | Molecular function | 2-oxoglutarate-dependent dioxygenase activity |
GO_0140683 | Molecular function | histone H3K9me/H3K9me2 demethylase activity |
GO_0003712 | Molecular function | transcription coregulator activity |
GO_0032452 | Molecular function | histone demethylase activity |
GO_0005506 | Molecular function | iron ion binding |
GO_0008270 | Molecular function | zinc ion binding |
GO_0035575 | Molecular function | histone H4K20 demethylase activity |
GO_0071558 | Molecular function | histone H3K27me2/H3K27me3 demethylase activity |
GO_0051864 | Molecular function | histone H3K36 demethylase activity |
Gene name | KDM7A |
Protein name | Lysine demethylase 7A Lysine-specific demethylase 7A (JmjC domain-containing histone demethylation protein 1D) (Lysine-specific demethylase 7) ([histone H3]-dimethyl-L-lysine9 demethylase 7A) (EC 1.14.11.65) |
Synonyms | KIAA1718 JHDM1D KDM7 |
Description | FUNCTION: Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code . Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3 . Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate . . |
Accessions | ENST00000397560.7 [Q6ZMT4-1] H9KVD6 ENST00000472616.1 Q6ZMT4 |