KDM7A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0006482Biological processprotein demethylation
GO_0006338Biological processchromatin remodeling
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0030901Biological processmidbrain development
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0032454Molecular functionhistone H3K9 demethylase activity
GO_0016706Molecular function2-oxoglutarate-dependent dioxygenase activity
GO_0140683Molecular functionhistone H3K9me/H3K9me2 demethylase activity
GO_0003712Molecular functiontranscription coregulator activity
GO_0032452Molecular functionhistone demethylase activity
GO_0005506Molecular functioniron ion binding
GO_0008270Molecular functionzinc ion binding
GO_0035575Molecular functionhistone H4K20 demethylase activity
GO_0071558Molecular functionhistone H3K27me2/H3K27me3 demethylase activity
GO_0051864Molecular functionhistone H3K36 demethylase activity

IV. Literature review

[source]
Gene nameKDM7A
Protein nameLysine demethylase 7A
Lysine-specific demethylase 7A (JmjC domain-containing histone demethylation protein 1D) (Lysine-specific demethylase 7) ([histone H3]-dimethyl-L-lysine9 demethylase 7A) (EC 1.14.11.65)
SynonymsKIAA1718
JHDM1D
KDM7
DescriptionFUNCTION: Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code . Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3 . Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate . .

AccessionsENST00000397560.7 [Q6ZMT4-1]
H9KVD6
ENST00000472616.1
Q6ZMT4